评估中国汉族人群中EFEMP1基因rs3791679多态性与胶质瘤风险之间的关联。
Assessing the association between EFEMP1 rs3791679 polymorphism and risk of glioma in a Chinese Han population.
作者信息
Jiang N, Peng Y P, Wang X Y, Dou C W, He W M
机构信息
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Department of Neurosurgery, Baogang Hospital, Baotou, Inner Mongolia, China.
出版信息
Genet Mol Res. 2016 Aug 26;15(3):gmr8279. doi: 10.4238/gmr.15038279.
In this study, we assessed the association between the EFEMP1 rs3791679 polymorphism and glioma risk in a Chinese Han population. A total of 94 glioma patients and 206 healthy controls who conformed to the inclusion and exclusion criteria were recruited from Baogang Hospital between March 2012 and October 2014. The EFEMP1 rs3791679 gene polymorphism was assessed using a polymerase chain reaction-restriction fragment length polymorphism assay and the results were statistically analyzed using SPSS Statistics 17.0. The results of unconditional logistic regression analysis revealed that the GG genotype of EFEMP1 rs3791679 was positively correlated with increased susceptibility to glioma (adjusted OR = 2.09, 95%CI = 1.21-7.81). Moreover, the GG genotype of EFEMP1 rs3791679 was correlated with higher risk of glioma compared to the AA+GA genotype (OR = 2.60, 95%CI = 1.08-6.28) in the regressive model. In conclusion, we report that the EFEMP1 rs3791679 polymorphism influences glioma susceptibility in the Chinese Han population.
在本研究中，我们评估了中国汉族人群中EFEMP1基因rs3791679多态性与胶质瘤风险之间的关联。2012年3月至2014年10月期间，从包钢医院招募了94例符合纳入和排除标准的胶质瘤患者和206名健康对照。采用聚合酶链反应-限制性片段长度多态性分析法评估EFEMP1基因rs3791679多态性，并使用SPSS Statistics 17.0对结果进行统计学分析。无条件逻辑回归分析结果显示，EFEMP1基因rs3791679的GG基因型与胶质瘤易感性增加呈正相关（校正比值比=2.09，95%可信区间=1.21-7.81）。此外，在回归模型中，与AA+GA基因型相比，EFEMP1基因rs3791679的GG基因型与更高的胶质瘤风险相关（比值比=2.60，95%可信区间=1.08-6.28）。总之，我们报道EFEMP1基因rs3791679多态性影响中国汉族人群的胶质瘤易感性。
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