铭记过去：一种新形式的基于蛋白质的遗传。
Remembering the Past: A New Form of Protein-Based Inheritance.
机构信息
Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.
出版信息
Cell. 2016 Oct 6;167(2):302-303. doi: 10.1016/j.cell.2016.09.036.
PMID:27716500
Abstract
A comprehensive analysis uncovered a set of yeast proteins promoting protein-based inheritance that shares many of the non-Mendelian properties of prions. Lacking any sequence or structural signatures of known prions, these proteins represent a new class of non-amyloid, protein-based epigenetic determinants that can control phenotype without impacting genotype.
摘要
一项全面的分析揭示了一组促进基于蛋白质的遗传的酵母蛋白，这些蛋白具有许多与朊病毒相似的非孟德尔特性。这些蛋白缺乏已知朊病毒的任何序列或结构特征，代表了一类新的非淀粉样蛋白、基于蛋白质的表观遗传决定因素，它们可以在不影响基因型的情况下控制表型。
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