源于海绵Halichondria sp.的氨基双环倍半萜烯类抗真菌化合物的构效关系
Structure-activity of antifungal compounds inspired by aminobisabolenes from the sponge Halichondria sp.
作者信息
Jamison Matthew T, Macho Jocelyn, Molinski Tadeusz F
机构信息
Department of Chemistry and Biochemistry and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
Department of Chemistry and Biochemistry and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
出版信息
Bioorg Med Chem Lett. 2016 Nov 1;26(21):5244-5246. doi: 10.1016/j.bmcl.2016.09.053. Epub 2016 Sep 22.
Structure-activity relationships of the antifungal aminobisabolene natural product, 1 isolated from Halichondria sp., and synthetic analogs were explored, in parallel with the antidermatophytic allylamine, Terbinafine®, against a panel of pathogenic fungi: Candida spp., Cryptococcus spp. and Trichophyton rubrum. Interpretation of the results suggest different modes of action in antifungal activity for the two classes of compounds.
研究了从Halichondria属物种中分离得到的抗真菌氨基没药烯天然产物1及其合成类似物的构效关系，并与抗皮肤真菌的烯丙胺类药物特比萘芬®一起针对一组致病真菌进行了研究，这些致病真菌包括念珠菌属、隐球菌属和红色毛癣菌。结果解释表明这两类化合物在抗真菌活性方面具有不同的作用模式。
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