米索硝唑在血吸虫性膀胱癌病例膀胱内给药后的渗透情况。
Penetration of misonidazole after intravesical administration in cases of carcinoma of the bilharzial bladder.
作者信息
Awwad H K, el-Merzabani M M, Burgers M V
出版信息
Br J Cancer Suppl. 1978 Jun;3:297-8.
Abstract
The penetration of misonidazole was studied by a semiquantitative T.L.C. method after intravesical administration 2 h before total cystectomy in cases of carcinoma of the Bilharzial bladder. In 5 out of 7 cases misonidazole was found at a concentration of the order of 0.4 mg/g in the superficial and deep parts of the tumour, but not in normal bladder tissues.
摘要
在血吸虫性膀胱癌患者全膀胱切除术前2小时膀胱内给药后，采用半定量薄层色谱法研究了米索硝唑的渗透情况。7例患者中有5例在肿瘤的浅表和深部发现米索硝唑浓度约为0.4mg/g，而在正常膀胱组织中未发现。
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