发展：为钟形帽敲响丧钟。
Development: For cloche the Bell Tolls.
机构信息
Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA 02115, USA. Department of Medical Oncology and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA 02115, USA. Department of Medical Oncology and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
出版信息
Curr Biol. 2016 Oct 10;26(19):R890-R892. doi: 10.1016/j.cub.2016.08.009.
A recent publication identifies npas4l as the gene defective in the well-known cloche mutant that lacks most endothelial as well as hematopoietic cells. This work poses intriguing questions as to the genetic and molecular nature of the origin of hemato-vascular lineages during early embryogenesis.
最近的一篇出版物确定了 npas4l 是基因缺陷的，这种基因缺陷存在于众所周知的 cloche 突变体中，该突变体缺乏大多数内皮细胞和造血细胞。这项工作提出了一些有趣的问题，即早期胚胎发生过程中造血血管谱系起源的遗传和分子性质。
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