促纤维增生性黑色素瘤：肿瘤学家面临的一项挑战。
Desmoplastic melanoma: a challenge for the oncologist.
作者信息
Manfredini Marco, Pellacani Giovanni, Losi Lorena, Maccaferri Monia, Tomasi Aldo, Ponti Giovanni
机构信息
Department of Surgical, Medical, Dental & Morphological Sciences with Interest Transplant, Oncological & Regenerative Medicine, Dermatology Unit, University of Modena & Reggio Emilia, Modena, Italy.
Department of Pathology, University of Modena & Reggio Emilia, Modena, Italy.
出版信息
Future Oncol. 2017 Feb;13(4):337-345. doi: 10.2217/fon-2016-0334. Epub 2016 Oct 12.
AIM
To evaluate clinical, pathologic and genetic features of desmoplastic melanoma (DM).
MATERIALS & METHODS: Analysis of all DM records from 1991 to 2015.
RESULTS
The most common location of DMs was the head and neck (69%); median age and follow-up were 60.5 and 7.3 years, respectively. A familial predisposition for DMs and others malignancies was analyzed. Thin Breslow thickness (<4.5 mm) was associated with an intraepidermal component or a previous lentigo maligna, whereas high Breslow thickness (>4.5 mm) was observed in 'pure' DM.
CONCLUSION
DM could progress from an early phase, characterized by an intraepidermal component, to late phase, characterized by a dermal nodule. This hypothesis correlates with melanoma genetic and NF1 mutation, which could be an early event in the progression of DM.
目的
评估促纤维增生性黑色素瘤（DM）的临床、病理及遗传学特征。
材料与方法
分析1991年至2015年期间所有DM病例记录。
结果
DM最常见的发病部位是头颈部（69%）；中位年龄和随访时间分别为60.5岁和7.3年。分析了DM及其他恶性肿瘤的家族易感性。薄的Breslow厚度（<4.5 mm）与表皮内成分或既往恶性雀斑有关，而厚的Breslow厚度（>4.5 mm）则见于“纯”DM。
结论
DM可从以表皮内成分为特征的早期阶段发展为以真皮结节为特征的晚期阶段。这一假说与黑色素瘤遗传学及NF1突变相关，而NF1突变可能是DM进展过程中的早期事件。
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