Kamihara Junne, Ma Clement, Fuentes Alabi Soad Linneth, Garrido Claudia, Frazier A Lindsay, Rodriguez-Galindo Carlos, Orjuela Manuela A
Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Department of Oncology, Benjamin Bloom National Children's Hospital, San Salvador, El Salvador.
Pediatr Blood Cancer. 2017 Feb;64(2):321-323. doi: 10.1002/pbc.26244. Epub 2016 Oct 13.
Global variations in the incidence of pediatric cancers have been described; however, the causes of such differences are not known. We investigated the relationship between the incidence of embryonal tumors and human development index on a global scale. Increasing incidence of neuroblastoma correlates significantly with an increasing index of human development, with greater incidence among countries with high socioeconomic development, in apparent contrast to the incidence of retinoblastoma. While more data are needed to corroborate this observation, our findings suggest new avenues for etiological research and serve as a call for support of population-based cancer registries in low-middle-income countries.
小儿癌症发病率的全球差异已有描述；然而，造成这种差异的原因尚不清楚。我们在全球范围内研究了胚胎性肿瘤发病率与人类发展指数之间的关系。神经母细胞瘤发病率的上升与人类发展指数的增加显著相关，在社会经济发展水平高的国家发病率更高，这与视网膜母细胞瘤的发病率形成明显对比。虽然需要更多数据来证实这一观察结果，但我们的研究结果为病因学研究提供了新途径，并呼吁支持中低收入国家基于人群的癌症登记。
