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The chemokine CXCR2 antagonist (AZD5069) preserves neutrophil-mediated host immunity in non-human primates.

作者信息

Uddin Mohib, Betts Catherine, Robinson Ian, Malmgren Anna, Humfrey Charles

机构信息

The IMED Respiratory, Inflammation & Autoimmunity Unit, AstraZeneca Gothenburg, Mölndal, Sweden.

Drug Safety and Metabolism, AstraZeneca R&D, Cambridge, U.K.

出版信息

Haematologica. 2017 Feb;102(2):e65-e68. doi: 10.3324/haematol.2016.152371. Epub 2016 Oct 14.

Abstract
摘要

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本文引用的文献

1
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Eur Respir J. 2015 Oct;46(4):1021-32. doi: 10.1183/13993003.00148-2015. Epub 2015 Sep 4.
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Br J Clin Pharmacol. 2015 Dec;80(6):1324-36. doi: 10.1111/bcp.12724. Epub 2015 Oct 2.
3
Targeting neutrophilic inflammation in severe neutrophilic asthma: can we target the disease-relevant neutrophil phenotype?
J Leukoc Biol. 2015 Oct;98(4):549-56. doi: 10.1189/jlb.3VMR1214-600RR. Epub 2015 May 14.
4
Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist.
J Pharmacol Exp Ther. 2015 May;353(2):340-50. doi: 10.1124/jpet.114.221358. Epub 2015 Mar 3.
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Am J Respir Crit Care Med. 2015 May 1;191(9):1001-11. doi: 10.1164/rccm.201405-0992OC.
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Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis.
J Cyst Fibros. 2013 May;12(3):241-8. doi: 10.1016/j.jcf.2012.08.016. Epub 2012 Sep 17.
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A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.
J Clin Invest. 2012 Jan;122(1):327-36. doi: 10.1172/JCI57990. Epub 2011 Dec 12.
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Role of neutrophils in innate immunity: a systems biology-level approach.
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