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肺部嗜酸性粒细胞疾病中的肿瘤溶解样综合征:一例报告及文献复习

Tumor Lysis-like Syndrome in Eosinophilic Disease of the Lung: A Case Report and Review of the Literature.

作者信息

Urae Seiya, Tsuruoka Kayori, Kuroya Sayaka, Shibagaki Yugo

机构信息

Division of Nephrology and Hypertension, St. Marianna University School of Medicine, Japan.

出版信息

Intern Med. 2016;55(20):3029-3034. doi: 10.2169/internalmedicine.55.6659. Epub 2016 Oct 15.

Abstract

Tumor lysis syndrome (TLS) is a metabolic disorder that is generally associated with a malignancy leading to hyperuricemia, hyperphosphatemia, and acute kidney injury. On the other hand, we sometimes encounter these phenomena in nonmalignant disease, which has been referred to as tumor lysis-like syndrome in some studies. We herein experienced a case in which tumor lysis-like syndrome occurred in the course of therapy for eosinophilic disease of the lung, a nonmalignant disease. Even in nonmalignant disease, massive cell lysis induced by therapy can cause phenomena such as TLS or tumor lysis-like syndrome.

摘要

肿瘤溶解综合征(TLS)是一种代谢紊乱,通常与恶性肿瘤相关,可导致高尿酸血症、高磷血症和急性肾损伤。另一方面,我们有时在非恶性疾病中也会遇到这些现象,在一些研究中,这被称为肿瘤溶解样综合征。我们在此报告一例在治疗肺部嗜酸性疾病(一种非恶性疾病)过程中发生肿瘤溶解样综合征的病例。即使在非恶性疾病中,治疗引起的大量细胞溶解也可导致诸如TLS或肿瘤溶解样综合征等现象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc1a/5109574/8db029d1240c/1349-7235-55-3029-g001.jpg

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