Urae Seiya, Tsuruoka Kayori, Kuroya Sayaka, Shibagaki Yugo
Division of Nephrology and Hypertension, St. Marianna University School of Medicine, Japan.
Intern Med. 2016;55(20):3029-3034. doi: 10.2169/internalmedicine.55.6659. Epub 2016 Oct 15.
Tumor lysis syndrome (TLS) is a metabolic disorder that is generally associated with a malignancy leading to hyperuricemia, hyperphosphatemia, and acute kidney injury. On the other hand, we sometimes encounter these phenomena in nonmalignant disease, which has been referred to as tumor lysis-like syndrome in some studies. We herein experienced a case in which tumor lysis-like syndrome occurred in the course of therapy for eosinophilic disease of the lung, a nonmalignant disease. Even in nonmalignant disease, massive cell lysis induced by therapy can cause phenomena such as TLS or tumor lysis-like syndrome.
肿瘤溶解综合征（TLS）是一种代谢紊乱，通常与恶性肿瘤相关，可导致高尿酸血症、高磷血症和急性肾损伤。另一方面，我们有时在非恶性疾病中也会遇到这些现象，在一些研究中，这被称为肿瘤溶解样综合征。我们在此报告一例在治疗肺部嗜酸性疾病（一种非恶性疾病）过程中发生肿瘤溶解样综合征的病例。即使在非恶性疾病中，治疗引起的大量细胞溶解也可导致诸如TLS或肿瘤溶解样综合征等现象。
