长期给予镉和乙醇会改变大鼠脑中的金属分布及一些生化物质。
Chronic cadmium-ethanol administration alters metal distribution and some biochemicals in rat brain.
作者信息
Murthy R C, Saxena D K, Lal B, Chandra S V
机构信息
Neurotoxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
出版信息
Biochem Int. 1989 Jul;19(1):135-43.
The effects of cadmium (100 ppm through drinking water) and ethanol (5 g/kg by gastric gavage) administration on biogenic amines, metal distribution and certain enzymes in rat brain was investigated after 90 days of exposure. Co-exposure group revealed significant accumulation of cadmium and also increase in zinc levels compared to all the other groups. Ethanol alone decreased MAO activity and increased NE and 5-HT level while in combination with Cd, these effects were more magnified. It is, therefore, suggested that the persons consuming alcohol may be more prone to the neurotoxic effects of this metal.
在暴露90天后，研究了通过饮用水给予镉（100 ppm）和通过胃管给予乙醇（5 g/kg）对大鼠脑中生物胺、金属分布和某些酶的影响。与所有其他组相比，联合暴露组显示镉有显著蓄积，锌水平也有所升高。单独给予乙醇会降低单胺氧化酶活性，增加去甲肾上腺素和5-羟色胺水平，而与镉联合使用时，这些影响会更加明显。因此，有人认为饮酒者可能更容易受到这种金属的神经毒性影响。
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