非分裂细胞病毒体影响体外和体内肿瘤细胞复制。

Non-dividing Cell Virtosomes Affect In Vitro and In Vivo Tumour Cell Replication.

作者信息

Garcia-Arranz Mariano, Garcia-Olmo Damian, Vega-Clemente Luz, Stroun Maurice, Gahan Peter B

机构信息

Cell Therapy Laboratory, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Avda Reyes Católicos 2, 28040, Madrid, Spain.

Surgery Department, Medicine School, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo s/n, 28029, Madrid, Spain.

出版信息

Adv Exp Med Biol. 2016;924:43-45. doi: 10.1007/978-3-319-42044-8_9.

DOI:10.1007/978-3-319-42044-8_9

PMID:27753017

Abstract

In vitro studies of partially purified virtosomes from rat liver showed inhibition of cell multiplication in four normal and two tumour cell lines. In vivo, the liver virtosomes slowed tumour growth and limited metastases in rats bearing DHD/K12-PROb cell initiated tumours.

摘要

对来自大鼠肝脏的部分纯化的病毒体进行的体外研究表明，其对四种正常细胞系和两种肿瘤细胞系的细胞增殖具有抑制作用。在体内，肝脏病毒体减缓了携带DHD/K12-PROb细胞引发肿瘤的大鼠的肿瘤生长并限制了转移。