Lee Y H, Song G G
Korea University College of Medicine, Korea University Medical Center Division of Rheumatology, Department of Internal Medicine Seoul Korea
Korea University College of Medicine, Korea University Medical Center Division of Rheumatology, Department of Internal Medicine Seoul Korea.
Cell Mol Biol (Noisy-le-grand). 2016 Sep 30;62(11):21-26.
This study aimed to determine whether Glutathione S-transferase M1 (GSTM1), P1 (GSTT1), NFKB1 polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). We performed a meta-analysis on the associations between GSTM1 and GSTT1 null genotypes, and NFKB1 -94 ins/delATTG polymorphisms and SLE. In total, seven studies were considered for this meta-analysis, which comprised 2,119 SLE patients and 3,014 healthy controls. Meta-analysis of the GSTM1 null polymorphism in 869 SLE and 1,544 control subjects revealed an association between SLE and the GSTM1 null genotype (OR = 1.321, 95% CI = 1.103-1.583, p = 0.002). Stratification by ethnicity indicated an association between the GSTM1 null genotype and SLE in Asians (OR = 1.334, 95% CI = 1.096-1.623, p = 0.004). However, meta-analysis of the GSTT1 null polymorphism, comprising 717 SLE and 1,008 control subjects, revealed no association between SLE and the GSTT1 null genotype overall (OR = 0.850, 95% CI = 0.687-1.051, p = 0.113) or in an Asian population (OR = 0.794, 95% CI = 0.594-1.061, p = 0.119). Meta-analysis of the NFKB1 -94 ins/delATTG polymorphism, comprising 1,250 SLE and 1,127 control subjects, revealed an association between SLE and the NFKB1 D allele (OR = 1.127, 95% CI = 1.011-1.257, p = 0.031). Ethnicity-specific meta-analysis revealed an association between the NFKB1 D allele and SLE in Asians (OR = 1.155, 95% CI = 1.026-1.300, p = 0.017). This meta-analysis demonstrates that the functional GSTM1 and NFKB1 polymorphisms are associated with the SLE risk in Asians.
本研究旨在确定谷胱甘肽S-转移酶M1（GSTM1）、P1（GSTT1）、NFKB1基因多态性是否会增加系统性红斑狼疮（SLE）的易感性。我们对GSTM1和GSTT1无效基因型、NFKB1 -94插入/缺失ATTG多态性与SLE之间的关联进行了荟萃分析。本荟萃分析共纳入七项研究，包括2119例SLE患者和3014例健康对照。对869例SLE患者和1544例对照者的GSTM1无效多态性进行荟萃分析，结果显示SLE与GSTM1无效基因型之间存在关联（OR = 1.321，95% CI = 1.103 - 1.583，p = 0.002）。按种族分层分析表明，亚洲人中GSTM1无效基因型与SLE之间存在关联（OR = 1.334，95% CI = 1.096 - 1.623，p = 0.004）。然而，对717例SLE患者和1008例对照者的GSTT1无效多态性进行荟萃分析，结果显示总体上SLE与GSTT1无效基因型之间无关联（OR = 0.850，95% CI = 0.687 - 1.051，p = 0.113），在亚洲人群中亦无关联（OR = 0.794，95% CI = 0.594 - 1.061，p = 0.119）。对1250例SLE患者和1127例对照者的NFKB1 -94插入/缺失ATTG多态性进行荟萃分析，结果显示SLE与NFKB1 D等位基因之间存在关联（OR = 1.127，95% CI = 1.011 - 1.257，p = 0.031）。按种族特异性进行的荟萃分析显示，亚洲人中NFKB1 D等位基因与SLE之间存在关联（OR = 1.155，95% CI = 1.026 - 1.300，p = 0.017）。本荟萃分析表明，功能性GSTM1和NFKB1基因多态性与亚洲人患SLE的风险相关。
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