Macfarlane Stephen, O'Connor Daniel
Hammond Care, Sydney.
Aged Mental Health Research Unit, Monash University, Melbourne.
Aust Prescr. 2016 Aug;39(4):123-125. doi: 10.18773/austprescr.2016.052. Epub 2016 Aug 1.
Most patients with dementia have some behavioural and psychological symptoms. While aggression and agitation are easily recognised, symptoms such as apathy may be overlooked. Behavioural and psychological symptoms should be managed without drugs whenever possible. Although there is little evidence to support their use, antipsychotic drugs are often prescribed to people with dementia. Before prescribing it is important to exclude other causes of altered behaviour, such as pain or infection. Some symptoms may be artefacts of memory loss rather than psychosis. Patients with dementia who are prescribed antipsychotic drugs have an increased risk of falls, hospitalisation and death. They should be regularly monitored for adverse effects. If the patient's symptoms resolve with drug treatment, reduce the dose after two or three months. Stop the drug if the symptoms do not return.
大多数痴呆患者会出现一些行为和心理症状。虽然攻击和激越行为容易识别,但冷漠等症状可能会被忽视。只要有可能,行为和心理症状应在不使用药物的情况下进行管理。尽管几乎没有证据支持使用抗精神病药物,但痴呆患者常被开具此类药物。在开药之前,排除行为改变的其他原因(如疼痛或感染)很重要。一些症状可能是记忆丧失的假象而非精神病。开具抗精神病药物的痴呆患者跌倒、住院和死亡的风险增加。应定期监测他们的不良反应。如果患者的症状通过药物治疗得到缓解,两三个月后减少剂量。如果症状未复发,则停药。