Delagrèverie Héloïse M, Delaugerre Constance, Lewin Sharon R, Deeks Steven G, Li Jonathan Z
INSERM U941, Université Paris Diderot, Laboratoire de Virologie, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris , France.
The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Australia; Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, Victoria, Australia.
Open Forum Infect Dis. 2016 Oct 7;3(4):ofw189. doi: 10.1093/ofid/ofw189. eCollection 2016 Oct.
In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are the major barrier to virus eradication and functional cure. Several therapeutic strategies to perturb, eliminate, and/or control this reservoir are now being pursued in the clinic. These strategies include latency reversal agents (LRAs) designed to reactivate HIV-1 ribonucleic acid transcription and virus production and a variety of immune-modifying drugs designed to reverse latency, block homeostatic proliferation, and replenish the viral reservoir, eliminate virus-producing cells, and/or control HIV replication after cessation of antiretroviral therapy. This review provides a summary of ongoing clinical trials of HIV LRAs and immunomodulatory molecules, and it highlights challenges in the comparison and interpretation of the expected trial results.
在慢性人类免疫缺陷病毒1型(HIV-1)感染中,长期潜伏感染的细胞是病毒根除和功能性治愈的主要障碍。目前临床上正在探索几种干扰、消除和/或控制这一病毒库的治疗策略。这些策略包括旨在重新激活HIV-1核糖核酸转录和病毒产生的潜伏逆转剂(LRA),以及多种免疫调节药物,这些药物旨在逆转潜伏状态、阻断稳态增殖、补充病毒库、消除病毒产生细胞和/或在抗逆转录病毒治疗停止后控制HIV复制。本综述总结了HIV LRA和免疫调节分子正在进行的临床试验,并强调了预期试验结果比较和解读中的挑战。