溶血磷脂酰乙醇胺分散体的多晶型相行为。热力学和光谱表征。

Polymorphic phase behavior of lysophosphatidylethanolamine dispersions. A thermodynamic and spectroscopic characterization.

作者信息

Slater J L, Huang C H, Adams R G, Levin I W

机构信息

Department of Biochemistry and Biophysics Program, University of Virginia School of Medicine, Charlottesville 22908.

出版信息

Biophys J. 1989 Aug;56(2):243-52. doi: 10.1016/S0006-3495(89)82670-0.

DOI:10.1016/S0006-3495(89)82670-0

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1280473/

Abstract

We have investigated the phase behavior of aqueous dispersions of a series of synthetic lysophosphatidylethanolamines as a function of the acyl chain length. Lysophosphatidylethanolamines exhibit phase polymorphism encompassing a well-ordered crystalline phase which may arise either from a metastable interdigitated lamellar gel phase or a metastable micellar phase. The time course of interconversion between these various phases have been outlined by observing the low temperature incubation time dependence of the calorimetric thermograms. We have determined differences in structure of these phases by Raman spectroscopy and 31P nuclear magnetic resonance spectroscopy. It appears that a principal contribution to this polymorphic phase behavior lies in the nature of headgroup hydration and headgroup-headgroup interactions.

摘要

我们研究了一系列合成溶血磷脂酰乙醇胺水分散体的相行为与酰基链长度的关系。溶血磷脂酰乙醇胺呈现相多态性，包括一种排列有序的晶相，该晶相可能源自亚稳的交错层状凝胶相或亚稳的胶束相。通过观察量热热谱图的低温孵育时间依赖性，概述了这些不同相之间相互转化的时间进程。我们通过拉曼光谱和31P核磁共振光谱确定了这些相的结构差异。看来，这种多晶型相行为的主要贡献在于头基水合作用和头基-头基相互作用的性质。

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