常染色体显性多囊病与可溶性肿瘤坏死因子相关凋亡诱导配体水平降低有关。
Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand.
作者信息
Sarı Funda, Yalçın Arzu Didem, Genç Gizem Esra, Sarıkaya Metin, Bisgin Atıl, Çetinkaya Ramazan, Gümüşlü Saadet
机构信息
Division of Nephrology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
出版信息
Balkan Med J. 2016 Sep;33(5):512-516. doi: 10.5152/balkanmedj.2016.150685. Epub 2016 Sep 1.
BACKGROUND
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple, large renal cysts and impaired kidney function. Although the reason for the development of kidney cysts is unknown, ADPKD is associated with cell cycle arrest and abundant apoptosis of renal tubular epithelial cells.
AIMS
We asked whether serum-soluble TNF-related apoptosis-inducing ligand (sTRAIL) might underlie ADPKD.
STUDY DESIGN
Case-control study.
METHODS
Serum sTRAIL levels were measured in 44 patients with ADPKD and 18 healthy volunteers. The human soluble TRAIL/Apo2L ELISA kit was used for the in vitro quantitative determination of sTRAIL in serum samples.
RESULTS
Mean serum sTRAIL levels were lower in patients with ADPKD as compared to the control group (446.9±103.1 and 875.9±349.6 pg/mL, p<0.001). Serum sTRAIL levels did not differ among stages of renal failure in patients with ADPKD. There was no correlation between serum sTRAIL levels and estimated glomerular filtration rate in patients with ADPKD (p>0.05).
CONCLUSION
Our results show that ADPKD patients have depressed sTRAIL levels, indicating apoptosis unrelated to the stage of chronic renal failure.
背景
常染色体显性遗传性多囊肾病（ADPKD）的特征是存在多个大肾囊肿且肾功能受损。尽管肾囊肿形成的原因尚不清楚，但ADPKD与细胞周期停滞及肾小管上皮细胞大量凋亡有关。
目的
我们探究血清可溶性肿瘤坏死因子相关凋亡诱导配体（sTRAIL）是否与ADPKD有关。
研究设计
病例对照研究。
方法
测定44例ADPKD患者和18名健康志愿者的血清sTRAIL水平。采用人可溶性TRAIL/Apo2L ELISA试剂盒对血清样本中的sTRAIL进行体外定量测定。
结果
与对照组相比，ADPKD患者的血清sTRAIL平均水平较低（分别为446.9±103.1和875.9±349.6 pg/mL，p<0.001）。ADPKD患者不同肾衰竭阶段的血清sTRAIL水平无差异。ADPKD患者的血清sTRAIL水平与估计肾小球滤过率之间无相关性（p>0.05）。
结论
我们的结果表明，ADPKD患者的sTRAIL水平降低，提示凋亡与慢性肾衰竭阶段无关。
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