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冷冻手术,器官局限性前列腺癌的一种替代治疗选择:泌尿外科医生的当前认知与实践模式

Cryosurgery, an alternative treatment option for organ-confined prostate cancer: current beliefs and practice patterns of urologists.

作者信息

Kongnyuy Michael, Halpern Daniel M, Kosinski Kaitlin E, Katz Aaron E

机构信息

Department of Urology, Winthrop University Hospital, 1300 Franklin Ave, Mineola, Garden City, NY, 11530, USA.

出版信息

Int Urol Nephrol. 2017 Jan;49(1):43-48. doi: 10.1007/s11255-016-1440-7. Epub 2016 Oct 19.

Abstract

PURPOSE

We aim to evaluate the current beliefs and practice patterns of urologists in regard to use of cryosurgery for management of PCa.

METHODS

An anonymous 13-point survey was designed and sent out to members of the Society of Urologic Oncology (SUO), Endourological Society (ES) and American College of Cryosurgery (ACC). Descriptive statistics and univariate analyses were used to determine variables associated with the use of cryosurgery.

RESULTS

Of the 206 responses received [81 (39.2 %) SUO; 106 (51.5 %) ES; 19 (9.2 %) ACC], 83 (40.3 %) performed cryosurgery. The majority of respondents who utilize cryosurgery do so in unilateral (80.3 %) and bilateral (77.6 %) intermediate-risk PCa. Also, users of this technology indicated significant use in primary treatment (>72 %), salvage treatment (>83 %), in patients who prefer cryosurgery (89.9 %) have a life expectancy ≥10 years (65.8 %) and poor erections (74.7 %). The main reason for not utilizing cryosurgery was the lack of technical expertise (56.7 %). A urologist in a non-academic practice setting was 3.2 times more likely to perform cryosurgery compared to a urologist in an academic setting, p = 0.0001.

CONCLUSION

Cryosurgery is increasingly being accepted among urologists. However, the need for large-scale studies as well as randomized clinical trials to further delineate the benefits of cryosurgery and convince the non-users and institutions cannot be overemphasized.

摘要

目的

我们旨在评估泌尿外科医生在使用冷冻手术治疗前列腺癌方面的当前观念和实践模式。

方法

设计了一项包含13个问题的匿名调查问卷,并发送给泌尿肿瘤学会(SUO)、腔内泌尿外科协会(ES)和美国冷冻外科学会(ACC)的成员。使用描述性统计和单因素分析来确定与冷冻手术使用相关的变量。

结果

在收到的206份回复中[81份(39.2%)来自SUO;106份(51.5%)来自ES;19份(9.2%)来自ACC],83人(40.3%)实施过冷冻手术。大多数使用冷冻手术的受访者用于单侧(80.3%)和双侧(77.6%)中危前列腺癌。此外,这项技术的使用者表示,该技术在初次治疗(>72%)、挽救性治疗(>83%)、患者倾向于选择冷冻手术(89.9%)、预期寿命≥10年(65.8%)以及勃起功能差(74.7%)的患者中应用广泛。不使用冷冻手术的主要原因是缺乏技术专长(56.7%)。与学术机构的泌尿外科医生相比,非学术机构的泌尿外科医生实施冷冻手术的可能性高3.2倍,p = 0.0001。

结论

冷冻手术越来越被泌尿外科医生所接受。然而,开展大规模研究以及随机临床试验以进一步阐明冷冻手术的益处并说服非使用者和机构的必要性再怎么强调也不为过。

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