Parto Parham, Lavie Carl J, Arena Ross, Bond Samantha, Popovic Dejana, Ventura Hector O
Department of Cardiovascular Diseases, John Ochsner Heart & Vascular Institute, Ochsner Clinical School-University of Queensland School of Medicine, 1514 Jefferson Highway, New Orleans, LA 70121, USA.
Department of Physical Therapy, Department of Kinesiology & Nutrition & Integrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Future Cardiol. 2016 Nov;12(6):639-653. doi: 10.2217/fca-2016-0029. Epub 2016 Oct 20.
The prevalence of obesity among adults and children worldwide has reached epic proportions and has become a major independent risk factor for the development of heart failure (HF), in addition to a contributor of hypertension and cardiovascular disease. The implications of obesity in the development of HF involve adverse effects on cardiac structure and function. Despite all of this, in the setting of chronic HF, excess body mass is associated with improved clinical outcomes, demonstrating the presence of an obesity paradox. In this review, we will discuss the gender differences, global application, potential mechanisms and role of interventions based on fitness and purposeful weight loss as potential therapeutic strategies.
全球范围内，成人和儿童肥胖的流行程度已达到惊人的比例，除了是高血压和心血管疾病的一个促成因素外，还已成为心力衰竭（HF）发生的一个主要独立危险因素。肥胖在HF发生过程中的影响涉及对心脏结构和功能的不良作用。尽管如此，在慢性HF的情况下，超重与改善的临床结局相关，这表明存在肥胖悖论。在本综述中，我们将讨论基于健康和有目的的体重减轻的干预措施作为潜在治疗策略的性别差异、全球应用、潜在机制及作用。
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