巴西人群动脉僵硬度的遗传力：Baependi心脏研究。
Heritability of arterial stiffness in a Brazilian population: Baependi Heart Study.
作者信息
Alvim Rafael O, Horimoto Andréa R V R, Oliveira Camila M, Bortolotto Luiz A, Krieger José E, Pereira Alexandre C
机构信息
aLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo bDepartment of Integrative Medicine, Center for Health Sciences, Federal University of Parana, Curitiba, Paraná cHypertension Unit, Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil.
出版信息
J Hypertens. 2017 Jan;35(1):105-110. doi: 10.1097/HJH.0000000000001133.
BACKGROUND
Increased arterial stiffness is an important determinant of cardiovascular disease risk. In addition, it has been recognized that arterial stiffness has familial aggregation; however, there are no studies involving Brazilian families. Thus, the aim of this study was to evaluate the heritability of arterial stiffness in a Brazilian population.
METHODS
In this study, 1675 eligible individuals (both sexes and aged 18-102 years) were distributed in 125 families resident in the municipality of Baependi, a city located in the southeast of Brazil. Carotid-femoral pulse wave velocity (PWV) was measured with a noninvasive automatic device (Complior; Artech Medical, Pantin, France). Variance component approaches, implemented in the SOLAR computer package (San Antonio, Texas, USA), were applied to estimate the heritability of the studied phenotype under different statistical models.
RESULTS
Heritability estimates for carotid-femoral PWV stratified by age ranging from 11 to 35% (higher in individuals aged ≤45 years and lower in individuals aged 18-102 years). Age and hypertension showed significant effects on the PWV trait and significantly affect heritability estimates in all models.
CONCLUSION
We conclude that the heritability of carotid-femoral PWV in a Brazilian population is intermediate, and therefore genetic studies evolving arterial stiffness phenotypes should be encouraged.
背景
动脉僵硬度增加是心血管疾病风险的重要决定因素。此外，人们已经认识到动脉僵硬度具有家族聚集性；然而，尚无涉及巴西家庭的研究。因此，本研究的目的是评估巴西人群中动脉僵硬度的遗传性。
方法
在本研究中，1675名符合条件的个体（男女皆有，年龄在18至102岁之间）分布在居住在巴西东南部城市巴彭迪市的125个家庭中。使用无创自动设备（Complior；法国潘坦市的Artech Medical公司）测量颈股脉搏波速度（PWV）。采用美国得克萨斯州圣安东尼奥市SOLAR计算机软件包中实施的方差成分法，在不同统计模型下估计所研究表型的遗传性。
结果
按年龄分层的颈股PWV遗传性估计值在11%至35%之间（≤45岁个体较高，18至102岁个体较低）。年龄和高血压对PWV性状有显著影响，并在所有模型中显著影响遗传性估计值。
结论
我们得出结论，巴西人群中颈股PWV的遗传性处于中等水平，因此应鼓励开展涉及动脉僵硬度表型的遗传学研究。
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