Solomon James P, Lowenthal Brett M, Kader A Karim, Parsons J Kellogg, Flaig Thomas W, Siefker-Radtke Arlene O, Dyrskjøt Lars, Hansel Donna E
Department of Pathology, University of California San Diego, San Diego, CA.
Department of Urology, University of California San Diego, San Diego, CA.
Urology. 2017 Apr;102:7-16. doi: 10.1016/j.urology.2016.10.014. Epub 2016 Oct 18.
Urothelial carcinoma can exhibit a wide variety of histopathologic phenotypes or variant morphologies, classifications of which have recently been revised in the 2016 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs. Many of these variants not only present diagnostic challenges, but also have clinical implications that affect patient prognosis and treatment strategies. This review will discuss these variant morphologies and their relationship to current understanding of the underlying biology of urothelial carcinoma and molecular classification paradigms.
尿路上皮癌可呈现多种组织病理学表型或变异形态，其分类在2016年世界卫生组织泌尿系统和男性生殖器官肿瘤分类中最近有所修订。这些变异中的许多不仅带来诊断挑战，还具有影响患者预后和治疗策略的临床意义。本综述将讨论这些变异形态及其与当前对尿路上皮癌潜在生物学的理解和分子分类范式的关系。
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