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青少年吸入剂滥用会导致其他药物使用及生长发育受损;对诊断的启示。

Adolescent inhalant abuse leads to other drug use and impaired growth; implications for diagnosis.

作者信息

Crossin Rose, Cairney Sheree, Lawrence Andrew J, Duncan Jhodie R

机构信息

Behavioural Neuroscience, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria.

Centre for Remote Health, Flinders University, Northern Territory.

出版信息

Aust N Z J Public Health. 2017 Feb;41(1):99-104. doi: 10.1111/1753-6405.12595. Epub 2016 Oct 23.

Abstract

OBJECTIVE

Abuse of inhalants containing the volatile solvent toluene is a significant public health issue, especially for adolescent and Indigenous communities. Adolescent inhalant abuse can lead to chronic health issues and may initiate a trajectory towards further drug use. Identification of at-risk individuals is difficult and diagnostic tools are limited primarily to measurement of serum toluene. Our objective was to identify the effects of adolescent inhalant abuse on subsequent drug use and growth parameters, and to test the predictive power of growth parameters as a diagnostic measure for inhalant abuse.

METHODS

We retrospectively analysed drug use and growth data from 118 Indigenous males; 86 chronically sniffed petrol as adolescents.

RESULTS

Petrol sniffing was the earliest drug used (mean 13 years) and increased the likelihood and earlier use of other drugs. Petrol sniffing significantly impaired height and weight and was associated with meeting 'failure to thrive' criteria; growth diagnostically out-performed serum toluene.

CONCLUSIONS

Adolescent inhalant abuse increases the risk for subsequent and earlier drug use. It also impairs growth such that individuals meet 'failure to thrive' criteria, representing an improved diagnostic model for inhalant abuse. Implications for Public Health: Improved diagnosis of adolescent inhalant abuse may lead to earlier detection and enhanced health outcomes.

摘要

目的

滥用含有挥发性溶剂甲苯的吸入剂是一个重大的公共卫生问题,尤其是对青少年和原住民社区而言。青少年滥用吸入剂会导致慢性健康问题,并可能引发进一步吸毒的轨迹。识别高危个体很困难,诊断工具主要限于血清甲苯测量。我们的目的是确定青少年滥用吸入剂对后续吸毒和生长参数的影响,并测试生长参数作为吸入剂滥用诊断指标的预测能力。

方法

我们回顾性分析了118名原住民男性的吸毒和生长数据;其中86人在青少年时期长期吸食汽油。

结果

吸食汽油是最早使用的毒品(平均13岁),增加了使用其他毒品的可能性和更早使用其他毒品的情况。吸食汽油显著损害身高和体重,并与符合“发育不良”标准相关;生长情况在诊断上优于血清甲苯。

结论

青少年滥用吸入剂会增加后续和更早吸毒的风险。它还会损害生长,使个体符合“发育不良”标准,这代表了一种改进的吸入剂滥用诊断模型。对公共卫生的影响:改善青少年吸入剂滥用的诊断可能会导致更早发现并改善健康结果。

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