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退伍军人冠状动脉旁路移植术后房颤的发生率、预测因素及影响

Incidence, Predictors, and Impact of Postoperative Atrial Fibrillation after Coronary Artery Bypass Grafting in Military Veterans.

作者信息

Omer Shuab, Cornwell Lorraine D, Bakshi Ankur, Rachlin Eric, Preventza Ourania, Rosengart Todd K, Coselli Joseph S, LeMaire Scott A, Petersen Nancy J, Pattakos Greg, Bakaeen Faisal G

出版信息

Tex Heart Inst J. 2016 Oct 1;43(5):397-403. doi: 10.14503/THIJ-15-5532. eCollection 2016 Oct.

Abstract

Little is known about the frequency and clinical implications of postoperative atrial fibrillation in military veterans who undergo coronary artery bypass grafting (CABG). We examined long-term survival data, clinical outcomes, and associated risk factors in this population. We retrospectively reviewed baseline, intraoperative, and postoperative data from 1,248 consecutive patients with similar baseline risk profiles who underwent primary isolated CABG at a Veterans Affairs hospital from October 2006 through March 2013. Multivariable logistic regression identified predictors of postoperative atrial fibrillation. Kaplan-Meier analysis was used to evaluate long-term survival (the primary outcome measure), morbidity, and length of hospital stay. Postoperative atrial fibrillation occurred in 215 patients (17.2%). Independent predictors of this sequela were age ≥65 years (odds ratios [95% confidence intervals], 1.7 [1.3-2.4] for patients of age 65-75 yr and 2.6 [1.4-4.8] for patients >75 yr) and body mass index ≥30 kg/m (2.0 [1.2-3.2]). Length of stay was longer for patients with postoperative atrial fibrillation than for those without (12.7 ± 6.6 vs 10.3 ± 8.9 d; ≤0.0001), and the respective 30-day mortality rate was higher (1.9% vs 0.4%; =0.014). Seven-year survival rates did not differ significantly. Older and obese patients are particularly at risk of postoperative atrial fibrillation after CABG. Patients who develop the sequela have longer hospital stays than, but similar long-term survival rates to, patients who do not.

摘要

对于接受冠状动脉旁路移植术(CABG)的退伍军人术后房颤的发生率及其临床意义,人们了解甚少。我们研究了这一人群的长期生存数据、临床结局及相关危险因素。我们回顾性分析了2006年10月至2013年3月期间在一家退伍军人事务医院接受首次单纯CABG且基线风险特征相似的1248例连续患者的基线、术中及术后数据。多变量逻辑回归确定了术后房颤的预测因素。采用Kaplan-Meier分析评估长期生存(主要结局指标)、发病率及住院时间。215例患者(17.2%)发生了术后房颤。该后遗症的独立预测因素为年龄≥65岁(65至75岁患者的比值比[95%置信区间]为1.7[1.3 - 2.4],>75岁患者为2.6[1.4 - 4.8])和体重指数≥30 kg/m²(2.0[1.2 - 3.2])。术后房颤患者的住院时间比未发生者更长(12.7±6.6天对10.3±8.9天;P≤0.0001),相应的30天死亡率更高(1.9%对0.4%;P = 0.014)。七年生存率无显著差异。年龄较大和肥胖的患者在CABG术后尤其有发生术后房颤的风险。发生该后遗症的患者住院时间比未发生者长,但长期生存率相似。

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