Baxter Richard H G
Department of Chemistry Dept. of Molecular Biophysics & Biochemistry Yale University PO Box 208107, New Haven CT 06520-8107, USA.
Chimia (Aarau). 2016 Oct;70(10):715-720. doi: 10.2533/chimia.2016.715.
Both historically and at present, vector control is the most generally effective means of controlling malaria transmission. Insecticides are the predominant method of vector control, but the sterile insect technique (SIT) is a complementary strategy with a successful track record in both agricultural and public health sectors. Strategies of genetic and radiation-induced sterilization of Anopheles have to date been limited by logistical and/or regulatory hurdles. A safe and effective mosquito chemosterilant would therefore be of major utility to future deployment of SIT for malaria control. Here we review the prior and current use of chemosterilants in SIT, and assess the potential for future research. Recent genomic and proteomic studies reveal opportunities for specific targeting of seminal fluid proteins, and the capacity to interfere with sperm motility and storage in the female.
从历史到现在，病媒控制都是控制疟疾传播最普遍有效的手段。杀虫剂是病媒控制的主要方法，但昆虫不育技术（SIT）是一种补充策略，在农业和公共卫生领域都有成功的记录。迄今为止，按蚊的遗传和辐射诱导绝育策略受到后勤和/或监管障碍的限制。因此，一种安全有效的蚊虫化学绝育剂对于未来将昆虫不育技术用于疟疾控制具有重要作用。在此，我们回顾化学绝育剂在昆虫不育技术中的既往和当前应用，并评估未来研究的潜力。最近的基因组和蛋白质组学研究揭示了针对精液蛋白进行特异性靶向的机会，以及干扰精子活力和在雌性体内储存的能力。
