Schoettler Michelle L, Graham Dionne, Tao Wen, Stack Margaret, Shu Elaine, Kerr Lauren, Neufeld Ellis J, Grace Rachael F
Pediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.
Institute for Relevant Clinical Data Analytics, Boston, Massachusetts.
Pediatr Blood Cancer. 2017 May;64(5). doi: 10.1002/pbc.26303. Epub 2016 Oct 26.
An observational approach is recommended in newly diagnosed children with immune thrombocytopenia (ITP) at low risk of bleeding; however, there is no standard definition of risk. A standardized clinical assessment and management plan (SCAMP ), a modifiable practice guideline, was implemented and revised (SCAMP-1 and SCAMP-2) and applied to 71 newly diagnosed patients with ITP. The Buchanan and Adix bleeding score guided treatment and was modified by stratifying by low- and high-risk grade 3 bleeding in SCAMP-2. Observation rates increased from 40% to 74% from SCAMP-1 to SCAMP-2 (P < 0.05) with no bleeding complications. We propose a modified bleeding score that increased observation rates in low-risk patients with ITP.
对于新诊断的出血风险较低的免疫性血小板减少症(ITP)患儿,建议采用观察性方法;然而,目前尚无风险的标准定义。实施并修订了标准化临床评估与管理计划(SCAMP),这是一项可修改的实践指南(SCAMP-1和SCAMP-2),并将其应用于71例新诊断的ITP患者。Buchanan和Adix出血评分指导治疗,并在SCAMP-2中根据3级低风险和高风险出血进行分层修改。从SCAMP-1到SCAMP-2,观察率从40%提高到74%(P<0.05),且无出血并发症。我们提出了一种改良的出血评分,可提高低风险ITP患者的观察率。