Hinsen Konrad, Kneller Gerald R
Centre de Biophysics. Moléculaire, CNRS, Rue Charles Sadron, 45071 Orléans, France.
J Chem Phys. 2016 Oct 21;145(15):151101. doi: 10.1063/1.4965881.
Anomalous diffusion is characterized by its asymptotic behavior for t → ∞. This makes it difficult to detect and describe in particle trajectories from experiments or computer simulations, which are necessarily of finite length. We propose a new approach using Bayesian inference applied directly to the observed trajectories sampled at different time scales. We illustrate the performance of this approach using random trajectories with known statistical properties and then use it for analyzing the motion of lipid molecules in the plane of a lipid bilayer.
反常扩散的特征在于其对于t→∞的渐近行为。这使得在实验或计算机模拟的粒子轨迹中难以检测和描述,因为这些轨迹必然是有限长度的。我们提出了一种新方法,使用贝叶斯推理直接应用于在不同时间尺度上采样的观测轨迹。我们使用具有已知统计特性的随机轨迹来说明这种方法的性能,然后将其用于分析脂质双层平面中脂质分子的运动。