制备β-氨甲基-β-苯甲酰基丙酸及相关的顺式β-氨甲基-γ-苯基-γ-丁内酯作为潜在抗菌剂。
Preparation of beta-aminomethyl-beta-benzoylpropionic acids and related cis beta-aminomethyl-gamma-phenyl-gamma-butyrolactones as potential antibacterial agents.
作者信息
Santana L, Cortizo L, Uriarte E, Garcia-Dominquez N, Raviña E, Garrido M J
出版信息
J Pharm Belg. 1989 Mar-Apr;44(2):121-6.
PMID:2778622
Abstract
The synthesis of beta-aminomethyl-beta-benzoylpropionic acids (V) and beta-aminomethyl-gamma phenylbutyrolactones (VI) is described. The cis stereochemistry of compounds VI was unambiguously established by NOE experiments carried out with Vla. Antibacterial activity was studied; MIC of each derivate was determined by agar dilution in Muller-Hinton medium and application of Steers' replicator.
摘要
描述了β-氨甲基-β-苯甲酰基丙酸（V）和β-氨甲基-γ-苯基丁内酯（VI）的合成。通过使用Vla进行的NOE实验明确确定了化合物VI的顺式立体化学。研究了抗菌活性；通过在Muller-Hinton培养基中进行琼脂稀释并使用Steers复制器来测定每种衍生物的最低抑菌浓度（MIC）。
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