Hernigou Philippe, Dubory Arnaud, Potage Damien, Roubineau François, Flouzat-Lachaniette Charles Henri
Orthopaedic Surgery, Hôpital Henri Mondor, University Paris East (UPEC), 94010, Creteil, France.
Hôpital Henri Mondor, University Paris East (UPEC), 94010, Creteil, France.
Int Orthop. 2017 Apr;41(4):757-763. doi: 10.1007/s00264-016-3319-8. Epub 2016 Oct 27.
Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) may require revision total knee replacement. Few studies have compared post-operative complications, results and risk of re-revision in RA and OA patients.
Forty-five RA patients who had undergone revision TKA from 1998 to 2010 were selected and matched with 45 OA patients who had revision during the same period. Results of the use of a revision postero-stabilized implant in osteoarthritis were compared to results of its use in inflammatory arthritis. With a mean follow-up of ten years (range, 5-17 years) we determined differences in comorbidities, risk for peri-operative adverse events, functional and radiological results, and risk of subsequent re-revision, between patients suffering from OA versus RA.
There were higher comorbidities, post-operative (<30 days) adverse events, and mortality at average ten years FU in RA than in OA patients. The mean overall changes in function scores were greater for the RA revision group when compared with the OA revision group. Taking steroids (Cox's regression, p = 0.001), and methotrexate or TNFα blockers (Cox's regression, p = 0.02) were not significant factors for radiolucent lines in RA and for loosening. At average ten years followup, patients with RA undergoing revision TKAs were not more likely to have a re-revision (4 among 45 patients; 9 %) than patients with OA undergoing revision in our department (7 patients; 15 %).
Similar results for the knee were observed in these two forms of arthritis in spite of the fact that the initial local joint status and general health status are worse in inflammatory rheumatoid arthritis than in "degenerative" osteoarthritis. However, complications were more frequent with RA.
类风湿性关节炎(RA)和骨关节炎(OA)患者可能需要进行全膝关节置换翻修手术。很少有研究比较RA和OA患者术后并发症、手术结果及再次翻修风险。
选取1998年至2010年期间接受全膝关节置换翻修手术的45例RA患者,并与同期接受翻修手术的45例OA患者进行匹配。比较在骨关节炎中使用后稳定型翻修植入物的结果与其在炎性关节炎中的使用结果。平均随访10年(范围5 - 17年),我们确定了OA患者与RA患者在合并症、围手术期不良事件风险、功能和影像学结果以及后续再次翻修风险方面存在的差异。
与OA患者相比,RA患者合并症更多,术后(<30天)不良事件更多,平均随访10年时死亡率更高。与OA翻修组相比,RA翻修组功能评分的总体平均变化更大。服用类固醇(Cox回归,p = 0.001)、甲氨蝶呤或肿瘤坏死因子α阻滞剂(Cox回归,p = 0.02)并非RA患者出现透光线和假体松动的显著因素。在平均随访10年时,我科接受全膝关节置换翻修手术的RA患者再次翻修的可能性(45例患者中有4例;9%)并不高于接受翻修手术的OA患者(7例患者;15%)。
尽管炎性类风湿性关节炎的初始局部关节状态和总体健康状况比“退行性”骨关节炎更差,但在这两种关节炎中观察到膝关节的结果相似。然而,RA患者的并发症更为常见。