Li Zhicen, Li Hao, Jiao Yuming, Ma Ji, Wang Shuo, Zhao Jizong, Cao Yong
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantanxili, Beijing, 100050, China.
China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China.
Childs Nerv Syst. 2017 Apr;33(4):595-600. doi: 10.1007/s00381-016-3278-9. Epub 2016 Oct 29.
The purpose of this study is to analyze and compare the clinicopathological characteristics and surgical outcomes between skull base and non-skull base meningiomas in pediatric population.
We retrospectively analyzed a total of 140 cases of pediatric meningiomas surgically treated in our department from January 2005 to July 2015 and compared the clinicopathological characteristics and surgical outcomes between skull base and non-skull base meningiomas.
Of all the pediatric meningiomas, 50 (35.8 %) were located at the skull base and 90 (64.2 %) were located at the non-skull base. Skull base and non-skull base meningiomas had a similar sex distribution (male/female = 1:1 in skull base meningiomas and male/female = 1.5:1 in non-skull base meningiomas) (P = 0.288) and high-grade meningioma occurrence rate (P = 0.569). In addition, the mean age of non-skull base meningiomas was 12.5 years which was younger than that of skull base meningiomas (14.2 years) (P = 0.019), and the preoperative tumor size was smaller in skull base (mean size = 4.7 cm in skull base meningiomas and mean size = 5.7 cm in non-skull base meningiomas) (P = 0.020). Gross total resection was achieved in 64 non-skull base patients (73.9 %) and 26 skull base patients (52 %) (P = 0.046). Patients with gross total resection had better progression free survival (PFS) than those with subtotal resection.
Pediatric skull base and non-skull base meningiomas are similar in sex distribution and high-grade meningioma occurrence rate. In comparison with non-skull base ones, pediatric skull base meningiomas occur at elder age and are smaller in size and they are more likely to be incompletely resected. Gross total resection and early treatment are recommended to prolong PFS of pediatric patients.
本研究旨在分析和比较儿童颅底脑膜瘤与非颅底脑膜瘤的临床病理特征及手术结果。
我们回顾性分析了2005年1月至2015年7月在我科接受手术治疗的140例儿童脑膜瘤病例，并比较了颅底脑膜瘤与非颅底脑膜瘤的临床病理特征及手术结果。
在所有儿童脑膜瘤中，50例（35.8%）位于颅底，90例（64.2%）位于非颅底。颅底脑膜瘤与非颅底脑膜瘤的性别分布相似（颅底脑膜瘤男女比例为1:1，非颅底脑膜瘤男女比例为1.5:1）（P = 0.288），高级别脑膜瘤发生率也相似（P = 0.569）。此外，非颅底脑膜瘤的平均年龄为12.5岁，低于颅底脑膜瘤（14.2岁）（P = 0.019），颅底脑膜瘤术前肿瘤大小较小（颅底脑膜瘤平均大小为4.7 cm，非颅底脑膜瘤平均大小为5.7 cm）（P = 0.020）。64例非颅底患者（73.9%）和26例颅底患者（52%）实现了肿瘤全切（P = 0.046）。肿瘤全切患者的无进展生存期（PFS）优于次全切除患者。
儿童颅底脑膜瘤与非颅底脑膜瘤在性别分布和高级别脑膜瘤发生率方面相似。与非颅底脑膜瘤相比，儿童颅底脑膜瘤发病年龄较大，肿瘤较小，且更有可能无法完全切除。建议进行肿瘤全切及早期治疗以延长儿童患者的PFS。
