两个细胞的故事：间充质干细胞与干细胞的独特关系。

A Tale of Two Cells: Telocyte and Stem Cell Unique Relationship.

作者信息

El Maadawi Zeinab M

机构信息

Histology & Cell Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

出版信息

Adv Exp Med Biol. 2016;913:359-376. doi: 10.1007/978-981-10-1061-3_23.

DOI:10.1007/978-981-10-1061-3_23

PMID:27796899

Abstract

Telocytes have been identified as a distinctive type of interstitial cells and have been recognized in most tissues and organs. Telocytes are characterized by having extraordinary long cytoplasmic processes, telopodes, that extend to form three-dimensional networks and commonly constitute specialized forms of cell-to-cell junctions with other neighboring cells. Telocytes have been localized in the stem cell niche of different organs such as the heart, lung, skeletal muscle, and skin. Electron microscopy and electron tomography revealed a specialized link between telocytes and stem cells that postulates a potential role for telocytes during tissue regeneration and repair. In this review, the distribution of telocytes in different stem cell niches will be explored, highlighting the intimate relationship between the two types of cells and their possible functional relationship.

摘要

端细胞已被鉴定为一种独特的间质细胞类型，并且在大多数组织和器官中都已被识别。端细胞的特征是具有超长的细胞质突起，即端粒，这些端粒延伸形成三维网络，并通常与其他相邻细胞构成特殊形式的细胞间连接。端细胞已定位在不同器官的干细胞微环境中，如心脏、肺、骨骼肌和皮肤。电子显微镜和电子断层扫描揭示了端细胞与干细胞之间的一种特殊联系，这表明端细胞在组织再生和修复过程中可能发挥作用。在这篇综述中，将探讨端细胞在不同干细胞微环境中的分布，突出这两种细胞类型之间的密切关系及其可能的功能联系。