Podoplanin作为卵巢癌肿瘤进展和淋巴管增殖的关键因素
Podoplanin as Key Player of Tumor Progression and Lymph Vessel Proliferation in Ovarian Cancer.
作者信息
Cobec Ionut Marcel, Sas Ioan, Pirtea Laurențiu, Cimpean Anca Maria, Moatar Aurica Elisabeta, Ceaușu Raluca Amalia, Raica Marius
机构信息
Department of Obstetrics and Gynecology, Angiogenesis Research Center, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
Department of Obstetrics and Gynecology, Diakonie Klinikum, Schwäbisch Hall, Academic Hospital of the Heidelberg University, Heidelberg, Germany.
出版信息
Anticancer Res. 2016 Oct;36(10):5265-5272. doi: 10.21873/anticanres.11097.
BACKGROUND/AIM: Podoplanin plays a key role in tumor progression and metastasis. We evaluated lymphatics proliferation rate and podoplanin expression in tumor cells of ovarian carcinoma.
MATERIALS AND METHODS
Seventy-five paraffin-embedded specimens of ovarian cancer were immunohistochemically assessed in order to quantify peritumoral (LMVDP) and intratumoral (LMVDT) lymphatic microvessel density of proliferating lymphatics and for podoplanin variability in tumor cells.
RESULTS AND CONCLUSION
LMVDT correlated with proliferating tumor vessels located in the peritumoral area (p=0.024) and with the number of mature vessels located in the intratumoral area (p<0.0001), while LMVDP correlated with peritumoral mature vessels (p<0.000l). Proliferating tumor cells at the invasive front were highly positive for podoplanin. To the best of our knowledge, this study represents the first assessment of lymphatic endothelial cell proliferation correlated with podoplanin expression in tumor cells from ovarian cancer. Our data support podoplanin as a potential target that may help reduce ovarian cancer dissemination and lymphatic metastasis.
背景/目的：血小板反应蛋白1在肿瘤进展和转移中起关键作用。我们评估了卵巢癌肿瘤细胞中的淋巴管增殖率和血小板反应蛋白1的表达。
材料与方法
对75例卵巢癌石蜡包埋标本进行免疫组织化学评估，以量化增殖淋巴管的瘤周（LMVDP）和瘤内（LMVDT）淋巴管微血管密度以及肿瘤细胞中血小板反应蛋白1的变异性。
结果与结论
LMVDT与位于瘤周区域的增殖肿瘤血管相关（p = 0.024），与位于瘤内区域的成熟血管数量相关（p < 0.0001），而LMVDP与瘤周成熟血管相关（p < 0.0001）。侵袭前沿的增殖肿瘤细胞血小板反应蛋白1呈高度阳性。据我们所知，本研究首次评估了与卵巢癌肿瘤细胞中血小板反应蛋白1表达相关的淋巴管内皮细胞增殖。我们的数据支持血小板反应蛋白1作为一个潜在靶点，可能有助于减少卵巢癌的播散和淋巴转移。
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