紫杉醇用于复发性头颈部鳞状细胞癌的放射化学疗法，该头颈部鳞状细胞癌先前已接受过放疗。

Radiochemotherapy with Paclitaxel for Recurrent Previously Irradiated Squamous Cell Carcinoma of the Head and Neck.

作者信息

Rades Dirk, Seidl Daniel, Wollenberg Barbara, Schild Steven E, Hakim Samer G

机构信息

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.

出版信息

Anticancer Res. 2016 Oct;36(10):5463-5468. doi: 10.21873/anticanres.11126.

DOI:10.21873/anticanres.11126

PMID:27798916

Abstract

BACKGROUND/AIM: Locoregional recurrences of squamous cell carcinoma of the head and neck (SCCHN) are difficult to treat. If radiotherapy was included in the primary treatment, another curative course of radiotherapy incurs substantial risk of complications. Results of re-irradiation can be improved by concurrent chemotherapy.

PATIENTS AND METHODS

Radiotherapy with low doses per fraction twice daily and paclitaxel were applied in four patients with recurrent SCCHN. Radiotherapy was administered with doses of 30-36 Gy and doses per fraction of 1.5 Gy twice daily. Concurrent chemotherapy consisted of 20-25 mg/m paclitaxel twice per week. Overall 1-year locoregional control following re-irradiation was 25%. One-year locoregional control rates were 75% inside the re-irradiated region and 50% outside the re-irradiated region. Distant metastases did not occur. One-year overall survival following re-irradiation was 75%. Toxicity did not exceed grade 2.

CONCLUSION

Re-irradiation plus concurrent paclitaxel appeared well-tolerated and resulted in promising outcomes.

摘要

背景/目的：头颈部鳞状细胞癌（SCCHN）的局部区域复发难以治疗。如果在初始治疗中包含放疗，再次进行根治性放疗会带来显著的并发症风险。同步化疗可改善再程放疗的效果。

患者与方法

对4例复发性SCCHN患者采用每日两次低分割放疗联合紫杉醇治疗。放疗剂量为30 - 36 Gy，每次分割剂量为1.5 Gy，每日两次。同步化疗方案为每周两次，每次20 - 25 mg/m²紫杉醇。再程放疗后的1年局部区域控制率为25%。再程放疗区域内的1年局部区域控制率为75%，再程放疗区域外为50%。未发生远处转移。再程放疗后的1年总生存率为75%。毒性未超过2级。