深静脉血栓形成：晚期胰腺腺癌的一个独立不良预后因素。
Deep Vein Thrombosis: An Independent Poor Prognosis Factor of Advanced Pancreatic Adenocarcinoma.
作者信息
Lambert Marc, Ploquin Anne, Declerck Lydie, Duhamel Alain, Makhloufi Samira, Turpin Anthony, Truant Stéphanie, Hebbar Mohamed
机构信息
Department of Internal Medicine, University Hospital, Lille, France.
Department of Medical Oncology, University Hospital, Lille, France.
出版信息
Anticancer Res. 2016 Oct;36(10):5527-5530. doi: 10.21873/anticanres.11135.
BACKGROUND/AIM: Pancreatic adenocarcinoma (PA) is frequently associated with venous thromboembolic events (VTEs). Although the prognostic value of VTEs remains controversial, these events can darken the prognosis. In contrast, because they necessitate anticoagulant therapy, some authors found that VTEs improved the prognosis. Indeed, anticoagulants could have an anti-tumor action. Therefore, we evaluated the prognostic value of VTEs in patients with locally advanced or metastatic PA.
PATIENTS AND METHODS
This retrospective study included all patients followed in a medical oncology Department. The prognostic value of tumor parameters, initial patients' characteristics and VTEs were subjected to univariate and multivariate analyses.
RESULTS
Based on 142 patients, analyses revealed independent pejorative prognostic value of: VTEs (hazard ratio (HR)=1.49 (95% confidence interval (CI)=1.03-2.15); p=0.03), interval between PA diagnosis and metastases occurrence (HR=0.97 (95% CI=0.94-0.99), p=0.02) and ≥1 metastatic sites (HR=1.82 (95% CI=1.076-3.087), p=0.02).
CONCLUSION
VTEs are an independent factor of poor prognosis in patients with advanced PA.
背景/目的：胰腺腺癌（PA）常与静脉血栓栓塞事件（VTE）相关。尽管VTE的预后价值仍存在争议，但这些事件会使预后变差。相反，由于需要进行抗凝治疗，一些作者发现VTE改善了预后。事实上，抗凝剂可能具有抗肿瘤作用。因此，我们评估了VTE在局部晚期或转移性PA患者中的预后价值。
患者与方法
这项回顾性研究纳入了肿瘤内科随访的所有患者。对肿瘤参数、患者初始特征和VTE的预后价值进行单因素和多因素分析。
结果
基于142例患者的分析显示，以下因素具有独立的不良预后价值：VTE（风险比（HR）=1.49（95%置信区间（CI）=1.03 - 2.15）；p = 0.03）、PA诊断与转移发生之间的间隔（HR = 0.97（95% CI = 0.94 - 0.99），p = 0.02）以及≥1个转移部位（HR = 1.82（95% CI = 1.076 - 3.087），p = 0.02）。
结论
VTE是晚期PA患者预后不良的独立因素。
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