肝细胞癌活体肝移植患者基于炎症的预后评分
Inflammation-based Prognostic Score in Patients with Living Donor Liver Transplantation for Hepatocellular Carcinoma.
作者信息
Harimoto Norifumi, Yoshizumi Tomoharu, Shimagaki Tomonari, Nagatsu Akihisa, Motomura Takashi, Harada Noboru, Okabe Hirohisa, Itoh Shinji, Ikegami Toru, Uchiyama Hideaki, Soejima Yuji, Maehara Yoshihiko
机构信息
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Anticancer Res. 2016 Oct;36(10):5537-5542. doi: 10.21873/anticanres.11137.
BACKGROUND
Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies.
PATIENTS AND METHODS
We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared. Risk factors for HCC recurrence were identified by univariate and multivariate analyses.
RESULTS
Both NLR and PLR were significantly increased in patients with recurrence. Multivariate analysis showed that des-gamma-carboxy prothrombin (DCP) ≥300 mAU/ml, NLR ≥2.66, <3 months between last HCC treatment to LDLT were independent predictors of DFS.
CONCLUSION
Preoperative NLR was an independent, inflammation-based prognostic marker of DFS and was predictive of recurrence following LDLT.
背景
基于炎症的预后评分，包括中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、改良格拉斯哥预后评分（mGPS）和预后营养指数（PNI），在各种恶性肿瘤中具有预后价值。
患者与方法
我们回顾性研究了它们在213例接受活体肝移植（LDLT）治疗肝细胞癌（HCC）患者中的预后价值。计算LDLT后的无病生存期（DFS）；比较复发患者和未复发患者的NLR、PLR、PNI和mGPS值。通过单因素和多因素分析确定HCC复发的危险因素。
结果
复发患者的NLR和PLR均显著升高。多因素分析显示，去γ-羧基凝血酶原（DCP）≥300 mAU/ml、NLR≥2.66、上次HCC治疗至LDLT间隔<3个月是DFS的独立预测因素。
结论
术前NLR是DFS的一个独立的、基于炎症的预后标志物，可预测LDLT后的复发。
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