Casahoursat L, Pham V H, Larrouture D, Heraud P, Etienne A
Pharm Acta Helv. 1989;64(8):225-30.
It was shown that the study of the infrared spectra of a drug and of the mixture drug + additives facilitates the preliminary studies for a tablet formulation. Thus, any interaction that may occur or affect the product stability can be detected and located. Furthermore, it was noticed that an interaction between an active ingredient and the various additives may modify the tablet desintegration time, but not necessarily the dissolution rate of this substance.
结果表明，对药物以及药物与添加剂混合物的红外光谱进行研究有助于开展片剂配方的初步研究。因此，可以检测并确定可能发生的或影响产品稳定性的任何相互作用。此外，还注意到活性成分与各种添加剂之间的相互作用可能会改变片剂的崩解时间，但不一定会改变该物质的溶解速率。
