带状疱疹患者的中风风险：一项系统评价和荟萃分析。
Risk of Stroke in Patients with Herpes Zoster: A Systematic Review and Meta-Analysis.
作者信息
Yang Sheng-Ye, Li Hong-Xing, Yi Xin-Hao, Han Guang-Liang, Zong Qiang, Wang Ming-Xing, Peng Xiao-Xiao
机构信息
Department of Dermatology, Shengli Oilfield Central Hospital, 31 Jinan Road, Dongying, Shandong 257000, China.
Department of Neurosurgery, Shengli Oilfield Central Hospital, 31 Jinan Road, Dongying, Shandong 257000, China.
出版信息
J Stroke Cerebrovasc Dis. 2017 Feb;26(2):301-307. doi: 10.1016/j.jstrokecerebrovasdis.2016.09.021. Epub 2016 Oct 31.
BACKGROUND
Several observational studies suggest that herpes zoster (HZ) may increase the risk of stroke, but the results are inconsistent. Our study was designed to assess the association between HZ and the risk of stroke through a meta-analysis of cohort studies.
METHODS
The electronic databases PubMed and EMBASE were searched from inception to May 31, 2016 to identify relevant cohort studies that assess the risk of stroke in patients with HZ. Reference lists were also reviewed to identify potential studies. The random-effects model and fixed-effects model were used to calculate the summary relative risks (RRs) with 95% confidence intervals (CIs).
RESULTS
Six cohort studies (251,076 HZ patients and 8462 cases of stroke) were identified in the study. The result showed that HZ was significantly correlated with increased risk of stroke, and the pooled RR was 1.36 (95% confidence interval [CI]: 1.10, 1.67) (P = .004). In the subgroup analysis, the significant association was observed except for stroke type (hemorrhage group). In the sensitivity analysis, excluding 1 study, the pooled RR was 1.45 (95% CI: 1.17, 1.80) (P = .001) for HZ, and 4.42 (95% CI: 2.75, 7.11) (P = .000) for herpes zoster ophthalmicus. Considerable heterogeneity was observed in our study.
CONCLUSION
Our study furnishes evidence of a positive association between HZ and the risk of stroke.
背景
多项观察性研究表明，带状疱疹（HZ）可能会增加中风风险，但结果并不一致。我们的研究旨在通过对队列研究的荟萃分析来评估HZ与中风风险之间的关联。
方法
检索电子数据库PubMed和EMBASE，检索时间从建库至2016年5月31日，以确定评估HZ患者中风风险的相关队列研究。还查阅了参考文献列表以确定潜在的研究。采用随机效应模型和固定效应模型计算汇总相对风险（RR）及95%置信区间（CI）。
结果
本研究共纳入6项队列研究（251,076例HZ患者和8462例中风病例）。结果显示，HZ与中风风险增加显著相关，汇总RR为1.36（95%置信区间[CI]：1.10，1.67）（P = 0.004）。在亚组分析中，除中风类型（出血组）外，均观察到显著关联。在敏感性分析中，排除1项研究后，HZ的汇总RR为1.45（95%CI：1.17，1.80）（P = 0.001），眼部带状疱疹的汇总RR为4.42（95%CI：2.75，7.11）（P = 0.000）。本研究观察到相当大的异质性。
结论
我们的研究提供了HZ与中风风险呈正相关的证据。
Zotero 插件