通过T1rho加权成像评估腮腺照射后的早期变化：一项初步研究。
Early Changes of Irradiated Parotid Glands Evaluated by T1rho-Weighted Imaging: A Pilot Study.
作者信息
Zhou Nan, Chu Chen, Dou Xin, Li Ming, Liu Song, Guo Tingting, Zhu Lijing, Liu Baorui, Chen Weibo, He Jian, Yan Jing, Zhou Zhengyang, Yang Xiaofeng
机构信息
From the *Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School; †Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine; ‡The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu Province; §Philips Healthcare, Shanghai, China; and ∥Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA.
出版信息
J Comput Assist Tomogr. 2017 May/Jun;41(3):472-476. doi: 10.1097/RCT.0000000000000547.
OBJECTIVE
The aim of the study was to confirm the feasibility of T1rho-weighted imaging to evaluate the dynamic changes of parotid glands in patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiation therapy.
METHODS
Twenty-six NPC patients (19 men; 7 women; mean [SD] age, 48.9 [13.4] years) underwent the following 3 serial T1rho-weighted imaging: within 2 weeks before radiotherapy (RT, pre-RT), 5 weeks after the beginning of RT (mid-RT), and 4 weeks after RT (post-RT). Parotid volumes, T1rho values, mean radiation doses, and xerostomia degrees were recorded. Change rates of parotid T1rho values were correlated with parotid atrophy rates, mean radiation doses, and xerostomia degrees.
RESULTS
During RT, parotid volume decreased (atrophy rate, 32.7 [8.1%] at mid-RT and 27.9 [10.0%] at post-RT compared with pre-RT; both P < 0.001) and parotid T1rho values increased (change rate, 25.0 [15.8%] at mid-RT and 30.1 [18.0%] at post-RT compared with pre-RT, both P < 0.001) significantly. The change rate of parotid T1rho value correlated with the atrophy rate significantly at post-RT (r = 0.301, P = 0.047). Intraobserver and interobserver reproducibility of parotid T1rho measurements were excellent (intraclass correlation coefficient, 0.974 and 0.956, respectively).
CONCLUSIONS
Dynamic changes of radiation-induced parotid damage in NPC patients who underwent intensity-modulated radiation therapy could be noninvasively evaluated by T1rho-weighted imaging.
目的
本研究旨在证实T1rho加权成像评估接受调强放射治疗的鼻咽癌（NPC）患者腮腺动态变化的可行性。
方法
26例NPC患者（19例男性；7例女性；平均[标准差]年龄，48.9[13.4]岁）接受了以下3次连续的T1rho加权成像：放疗（RT）前2周内（放疗前，pre-RT）、RT开始后5周（放疗中期，mid-RT）和RT后4周（放疗后，post-RT）。记录腮腺体积、T1rho值、平均放射剂量和口干程度。腮腺T1rho值的变化率与腮腺萎缩率、平均放射剂量和口干程度相关。
结果
放疗期间，腮腺体积减小（与放疗前相比，放疗中期萎缩率为32.7[8.1%]，放疗后为27.9[10.0%]；P均<0.001），腮腺T1rho值显著增加（与放疗前相比，放疗中期变化率为25.0[15.8%]，放疗后为30.1[18.0%]；P均<0.001）。放疗后腮腺T1rho值的变化率与萎缩率显著相关（r = 0.301，P = 0.047）。腮腺T1rho测量的观察者内和观察者间重复性良好（组内相关系数分别为0.974和0.956）。
结论
接受调强放射治疗的NPC患者放疗引起的腮腺损伤动态变化可通过T1rho加权成像进行无创评估。
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