Blom Rianne M, van Wingen Guido A, van der Wal Sija J, Luigjes Judy, van Dijk Milenna T, Scholte H Steven, Denys Damiaan
Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
PLoS One. 2016 Nov 10;11(11):e0165789. doi: 10.1371/journal.pone.0165789. eCollection 2016.
Body Integrity Identity Disorder (BIID) is a condition in which individuals perceive a mismatch between their internal body scheme and physical body shape, resulting in an absolute desire to be either amputated or paralyzed. The condition is hypothesized to be of congenital nature, but evidence for a neuro-anatomical basis is sparse.
We collected T1-weighted structural magnetic resonance imaging scans on a 3T scanner in eight individuals with BIID and 24 matched healthy controls, and analyzed the data using voxel-based morphometry.
The results showed reduced grey matter volume in the left dorsal and ventral premotor cortices and larger grey matter volume in the cerebellum (lobule VIIa) in individuals with BIID compared to controls.
The premotor cortex and cerebellum are thought to be crucial for the experience of body-ownership and the integration of multisensory information. Our results suggest that BIID is associated with structural brain anomalies and might result from a dysfunction in the integration of multisensory information, leading to the feeling of disunity between the mental and physical body shape.
身体完整性认同障碍（BIID）是一种个体感觉其内在身体图式与身体外形不匹配，从而产生截肢或瘫痪的强烈愿望的病症。该病症被推测为先天性的，但神经解剖学基础的证据稀少。
我们在3T扫描仪上收集了8名患有BIID的个体和24名匹配的健康对照者的T1加权结构磁共振成像扫描数据，并使用基于体素的形态测量法对数据进行分析。
结果显示，与对照组相比，患有BIID的个体左侧背侧和腹侧运动前皮质的灰质体积减少，小脑（小叶VIIa）的灰质体积增大。
运动前皮质和小脑被认为对身体所有权的体验和多感官信息的整合至关重要。我们的结果表明，BIID与大脑结构异常有关，可能是由于多感官信息整合功能障碍导致心理和身体外形之间的不统一感。
