Liu Xiaowen, Perakakis Nikolaos, Gong Huizhi, Chamberland John P, Brinkoetter Mary T, Hamnvik Ole-Petter R, Mantzoros Christos S
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Metabolism. 2016 Dec;65(12):1720-1730. doi: 10.1016/j.metabol.2016.09.003. Epub 2016 Sep 22.
Obesity is associated with chronic low-grade inflammation leading to insulin resistance and diabetes. Adiponectin is an adipokine that regulates inflammatory responses. The aim of our study was to investigate whether any effects of adiponectin against obesity and insulin-resistance may depend on the adaptive immune system.
We treated high-fat-diet fed Rag1-/- mice lacking mature lymphocytes with adiponectin over 7weeks and investigated alterations in their metabolic outcome and inflammatory state.
Adiponectin protects from weight gain despite a small compensatory stimulation of energy intake in mice lacking an adaptive immune system. Additionally, adiponectin protects from dysglycemia. Minor alterations in the macrophage phenotype, but not in the circulating cytokine levels, may contribute to the protective role of adiponectin against hyperglycemia and diabetes.
Adiponectin or agents increasing adiponectin may be a promising therapeutic option against obesity and hyperglycemia in immune-deficient populations.
肥胖与导致胰岛素抵抗和糖尿病的慢性低度炎症相关。脂联素是一种调节炎症反应的脂肪因子。我们研究的目的是调查脂联素对肥胖和胰岛素抵抗的任何影响是否可能取决于适应性免疫系统。
我们对缺乏成熟淋巴细胞的高脂饮食喂养的Rag1-/-小鼠用脂联素治疗7周,并研究其代谢结果和炎症状态的变化。
尽管缺乏适应性免疫系统的小鼠能量摄入有小的代偿性刺激,但脂联素可防止体重增加。此外,脂联素可预防血糖异常。巨噬细胞表型的轻微改变,而非循环细胞因子水平的改变,可能有助于脂联素对高血糖和糖尿病的保护作用。
脂联素或增加脂联素的药物可能是免疫缺陷人群对抗肥胖和高血糖的有前景的治疗选择。