Calvo Cristina, Gallardo Paula, Torija Patricia, Bellón Sara, Méndez-Echeverría Ana, Del Rosal Teresa, Baquero-Artigao Fernando, Sainz Talía, Romero María, Cabrerizo María
Pediatrics Department, Hospital Severo Ochoa, Leganés, Madrid, Spain; Pediatric and Infectious Diseases, Hospital La Paz, La Paz Research Insititute (IdiPAZ), Madrid, Spain.
Pediatrics Department, Hospital Severo Ochoa, Leganés, Madrid, Spain.
J Clin Virol. 2016 Dec;85:37-39. doi: 10.1016/j.jcv.2016.10.020. Epub 2016 Nov 3.
Very little information exists on simultaneous infections by viruses and bacteria in infants with fever without source (FWS).
To investigate the incidence of bacterial coinfection in infants up to 3 months of age with neurological viral infection.
Prospective study performed in infants below 90 days of age attending the emergency room of two public hospitals in Spain for FWS. Those who had viral screening performed in CSF, together with blood, CSF and urine cultures were included. Herpes virus, EV and HPeV detection in CSF was performed by PCR. Coinfections between viruses in CSF and serious bacterial infections were described.
119 Infants less than 90 days of age were recruited. Forty-five (38%) had viral infection of the central nervous system, and in 8 of them (17.7%) we found a concurrent bacterial infection: 7 urinary tract infections (UTI) and 1 sepsis. In all cases, the virus identified in CSF was EV.
Bacterial infections were frequent in young infants with viral neurological infections associated to EV. Urinary tract infection was the most common bacterial disease.
关于无明确病因发热（FWS）婴儿中病毒和细菌同时感染的信息非常少。
调查3个月及以下患有神经性病毒感染婴儿中细菌合并感染的发生率。
对西班牙两家公立医院急诊科就诊的90日龄以下因FWS的婴儿进行前瞻性研究。纳入那些进行了脑脊液病毒筛查以及血培养、脑脊液培养和尿培养的婴儿。通过聚合酶链反应（PCR）检测脑脊液中的疱疹病毒、肠道病毒（EV）和人细小病毒B19（HPeV）。描述了脑脊液中病毒之间的合并感染以及严重细菌感染情况。
招募了119名90日龄以下婴儿。45名（38%）患有中枢神经系统病毒感染，其中8名（17.7%）发现有合并细菌感染：7例尿路感染（UTI）和1例败血症。所有病例中，脑脊液中鉴定出的病毒均为EV。
在与EV相关的病毒性神经感染的幼儿中，细菌感染很常见。尿路感染是最常见的细菌性疾病。
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