Coste Thibaut, Caiazzo Robert, Torres Fanelly, Vantyghem Marie Christine, Carnaille Bruno, Do Cao Christine, Douillard Claire, Pattou François
Department of General and Endocrine Surgery, CHU Lille, Rue Michel Polonovski, 59000, Lille, France.
Department of Endocrinology, CHU Lille, 59000, Lille, France.
Surg Endosc. 2017 Jul;31(7):2743-2751. doi: 10.1007/s00464-016-4830-0. Epub 2016 Nov 10.
Laparoscopic adrenalectomy (LA) has become the standard technique for most indications. The aim of this study was to determine the predictive factors of intra- and postoperative complications in order to inform the orientation of patient to a surgeon with more experience in adrenal surgery.
From January 1994 to December 2013, 520 consecutive patients benefited from LA at Huriez Hospital, Lille, France. Each complication was graded according to the Dindo-Clavien-grade scale. The predictive factors of complications were determined by logistic regression.
Fifty-two surgeons under the supervision of 5 senior surgeons (individual experience >30 LA) participated. Postoperative complications with a grade of ≥2 occurred in 52 (10 %) patients (29 (5.6 %) medical, 19 (3.6 %) surgical, and 4 (0.8 %) mixed complications) leading to 12 (2.3 %) reoperations. There was no postoperative death. Intraoperative complication happened in 81 (15.6 %) patients responsible for conversion to open adrenalectomy (OA) [odds ratio (OR) 13.9, CI 95 % 4.74-40.77, p < 0.001]. History of upper mesocolic or retroperitoneal surgery was predictive of intraoperative complication (OR 2.02, 1.05-3.91, p = 0.036). Lesion diameter ≥45 mm was predictive of intraoperative complication (OR 1.94, 1.19-3.15, p = 0.008), conversion to OA (OR 7.46, 2.18-25.47, p = 0.001), and adrenal capsular breach (OR 4.416, 1.628-11.983, p = 0.004). Conversion to OA was the main predictive factor of postoperative complications (OR 5.42, 1.83-16.01, p = 0.002). Under adequate supervision, the surgeon's individual experience and initial adrenal disease were not considered predictive of complications.
Lesion diameter over 45 mm is the determinant parameter for guidance of patients to surgeons with more extensive experience.
腹腔镜肾上腺切除术(LA)已成为大多数适应证的标准术式。本研究旨在确定术中和术后并发症的预测因素,以便为患者选择更有肾上腺手术经验的外科医生提供参考。
1994年1月至2013年12月,法国里尔市于里耶医院连续520例患者接受了LA手术。每种并发症均根据Dindo-Clavien分级量表进行分级。并发症的预测因素通过逻辑回归分析确定。
52名外科医生在5名资深外科医生(个人经验>30例LA手术)的指导下参与了研究。52例(10%)患者发生了≥2级的术后并发症(29例(5.6%)为内科并发症,19例(3.6%)为外科并发症,4例(0.8%)为混合并发症),导致12例(2.3%)患者再次手术。无术后死亡病例。81例(15.6%)患者发生术中并发症,导致中转开放肾上腺切除术(OA)[比值比(OR)13.9,95%可信区间(CI)4.74 - 40.77,p < 0.001]。中结肠上区或腹膜后手术史是术中并发症的预测因素(OR 2.02,1.05 - 3.91,p = 0.036)。病灶直径≥45 mm是术中并发症(OR 1.94,1.19 - 3.15,p = 0.008)、中转OA(OR 7.46,2.18 - 25.47,p = 0.001)和肾上腺包膜破裂(OR 4.416,1.628 - 11.983,p = 0.004)的预测因素。中转OA是术后并发症的主要预测因素(OR 5.42,1.83 - 16.01,p = 0.002)。在充分的指导下,外科医生的个人经验和初始肾上腺疾病不被认为是并发症的预测因素。
病灶直径超过45 mm是指导患者选择经验更丰富外科医生的决定性参数。