稳定的盘状双分子层囊泡：用于细胞递送的脂质纳米载体平台。
Stable Discoidal Bicelles: A Platform of Lipid Nanocarriers for Cellular Delivery.
作者信息
Liu Ying, Xia Yan, Rad Armin Tahmasbi, Aresh Wafa, Nieh Mu-Ping
机构信息
Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Department of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
出版信息
Methods Mol Biol. 2017;1522:273-282. doi: 10.1007/978-1-4939-6591-5_22.
Bicellar mixtures have been used as alignable membrane substrates for the structural characterization of membrane-associated proteins. Most recently, it has been shown that bicelles can serve as nanocarriers to effectively deliver hydrophobic molecules to cancer cells with a 3- to 10-fold enhancement compared to that of chemically identical liposomes. In this chapter, a detailed preparation protocol, common structural characterization methods, the structural stability and the cellular uptake of bicellar nanodisks are discussed.
双分子层混合物已被用作可排列的膜底物，用于膜相关蛋白的结构表征。最近的研究表明，双分子层囊泡可以作为纳米载体，与化学组成相同的脂质体相比，能以3至10倍的效率将疏水分子有效递送至癌细胞。在本章中，将讨论双分子层纳米盘的详细制备方案、常见的结构表征方法、结构稳定性以及细胞摄取情况。
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