泌尿道脓毒症的分类与管理更新
An update on classification and management of urosepsis.
作者信息
Wagenlehner Florian M E, Tandogdu Zafer, Bjerklund Johansen Truls E
机构信息
aClinic for Urology, Pediatric Urology and Andrology, Justus-Liebig University Giessen, Giessen, Germany bNewcastle University Northern Institute for Cancer Research, Newcastle Upon Tyne, UK cDepartment of Urology, Oslo University Hospital, Oslo, Norway.
出版信息
Curr Opin Urol. 2017 Mar;27(2):133-137. doi: 10.1097/MOU.0000000000000364.
PURPOSE OF REVIEW
The urinary tract is the infection site in severe sepsis/septic shock in 10-30%.
RECENT FINDINGS
There is a new Sepsis definition focusing on severe sepsis. Urosepsis is mainly due to obstructed uropathy of the upper urinary tract. The pathogenesis of sepsis is complex and is driven by the innate immune system. In the further course immunosuppression is developing.Management of urosepsis includes early diagnosis, early initiation of treatment such as identification and control of the complicating factor in the urinary tract and the specific sepsis therapy. As part of early diagnosis the value of the new defining criteria is still to be known. The management bundles are regularly updated according to the surviving sepsis campaign guidelines.
SUMMARY
Sepsis has still a high morbidity and mortality rate. Although definition and diagnosis of sepsis has been recently updated, its translation into urosepsis management requires validation.
综述目的
在严重脓毒症/脓毒性休克中，泌尿道是10%-30%的感染部位。
最新发现
有一个新的脓毒症定义聚焦于严重脓毒症。尿脓毒症主要由上尿路梗阻性疾病引起。脓毒症的发病机制复杂，由先天免疫系统驱动。在后续病程中会出现免疫抑制。尿脓毒症的管理包括早期诊断、早期开始治疗，如识别和控制尿路中的复杂因素以及特定的脓毒症治疗。作为早期诊断的一部分，新定义标准的价值仍有待明确。管理集束根据拯救脓毒症运动指南定期更新。
总结
脓毒症的发病率和死亡率仍然很高。尽管脓毒症的定义和诊断最近有所更新，但其在尿脓毒症管理中的应用仍需验证。
Zotero 插件