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Reid阴道镜指数与瑞典评分与宫颈组织学关联强度的比较

A Comparison of the Strength of Association of Reid Colposcopic Index and Swede Score With Cervical Histology.

作者信息

Ranga Renu, Rai Shweta, Kumari Aruna, Mathur Sandeep, Kriplani Alka, Mahey Reeta, Agarwal Nutan, Kachhawa Garima, Vanamail Perumal, Bhatla Neerja

机构信息

1Department of Obstetrics and Gynaecology, and 2Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Low Genit Tract Dis. 2017 Jan;21(1):55-58. doi: 10.1097/LGT.0000000000000278.

Abstract

OBJECTIVE

Colposcopic scoring systems provide an objective diagnosis and select patients who require treatment. A new scoring system, Swede score, has added lesion size as a parameter. This study aimed to compare the strength of association of Reid colposcopic index versus Swede score and assess their utility in low-resource settings.

METHODS

In this prospective study, 150 women aged 30 to 59 years with abnormal screening result were enrolled. All women underwent colposcopy; the findings were scored by both Reid colposcopic index and Swede score, biopsy taken from all abnormal areas. Performances of both the scores were calculated.

RESULTS

A total of 33 (22%) CIN 2+ lesions were detected. Reid colposcopic index at a cutoff of 5 had sensitivity, specificity, positive predictive value, and negative predictive value for detecting CIN2+ lesions of 96.97%, 95.35%, 88.89%, and 98.8%, respectively. Using Swede score at a cutoff of 8, sensitivity, specificity, positive predictive value, and negative predictive value were 42.42%, 100%, 100%, and 81.9%, and with a cutoff of 5, these were 100%, 88.37%, 76.74%, and 100%, respectively. The correlation coefficient (R) was 0.919. By Spearman rank correlation coefficient, the strength of correlation between Swede score and RCI was 0.937 (p < .001).

CONCLUSIONS

Swede score can be used flexibly depending on the setting. The lower threshold (5) with high sensitivity can be used for screening, whereas the higher threshold (8) with high specificity can be used for screen-and-treat selection to decrease the overtreatment rate. Thus, it is a more attractive option for cancer prevention programs in low-resource settings.

摘要

目的

阴道镜评分系统可提供客观诊断并筛选出需要治疗的患者。一种新的评分系统——瑞典评分,已将病变大小作为一个参数纳入。本研究旨在比较里德阴道镜指数与瑞典评分的关联强度,并评估它们在资源匮乏地区的实用性。

方法

在这项前瞻性研究中,纳入了150名年龄在30至59岁之间、筛查结果异常的女性。所有女性均接受了阴道镜检查;检查结果同时采用里德阴道镜指数和瑞典评分进行评分,并从所有异常区域取活检。计算两种评分的性能。

结果

共检测到33例(22%)CIN 2+病变。里德阴道镜指数截断值为5时,检测CIN2+病变的敏感性、特异性、阳性预测值和阴性预测值分别为96.97%、95.35%、88.89%和98.8%。瑞典评分截断值为8时,敏感性、特异性、阳性预测值和阴性预测值分别为42.42%、100%、100%和81.9%;截断值为5时,这些指标分别为100%、88.37%、76.74%和100%。相关系数(R)为0.919。通过斯皮尔曼等级相关系数,瑞典评分与里德阴道镜指数之间的相关强度为0.937(p < .001)。

结论

瑞典评分可根据具体情况灵活使用。低阈值(5)具有高敏感性,可用于筛查;而高阈值(8)具有高特异性,可用于筛查并治疗的选择,以降低过度治疗率。因此,对于资源匮乏地区的癌症预防项目而言,它是一个更具吸引力的选择。

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