TLE1在癌症中的功能及治疗潜力。
TLE1 function and therapeutic potential in cancer.
作者信息
Yuan Da, Yang Xue, Yuan Zhenpeng, Zhao Yanqing, Guo Junchao
机构信息
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
出版信息
Oncotarget. 2017 Feb 28;8(9):15971-15976. doi: 10.18632/oncotarget.13278.
Abstract
Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 could be used as a diagnostic marker and is a possible therapeutic target in various malignancies. It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In this review, we highlight the functions of TLE1 in cancer and explore targeted approaches for cancer diagnosis and treatment. In particular, we discuss the TLE1 function in pancreatic cancer.
摘要
格鲁乔（Gro）/类转导素分裂增强子（TLE）家族蛋白作为许多转录因子的共抑制因子，参与关键信号通路。TLE1对炎症起负调节作用，并在包括癌症在内的多种疾病中具有潜在作用。先前的研究表明，TLE1可作为诊断标志物，并且是各种恶性肿瘤可能的治疗靶点。因此，阐明TLE1在癌症发生和转移过程中发挥功能的机制非常重要。在本综述中，我们重点介绍了TLE1在癌症中的功能，并探讨了癌症诊断和治疗的靶向方法。特别是，我们讨论了TLE1在胰腺癌中的功能。
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