Successful treatment of a patient with Reiter's syndrome and acquired immunodeficiency syndrome using etretinate.

In a 30-year-old homosexual man with a 3-year history of localized psoriasis, an oligoarthropathy and severe cutaneous lesions of Reiter's syndrome developed 6 months after acquired immunodeficiency syndrome (AIDS) was diagnosed. Reiter's syndrome and psoriasis may be a continuum of similarly expressed cutaneous diseases that develop in genetically predisposed individuals. We discuss the possible involvement of T lymphocytes and Langerhans cells in the cutaneous lesions of AIDS patients with psoriasis and Reiter's syndrome. In these AIDS patients, skin disease tends to be severe and recalcitrant to conventional therapy. Etretinate plus topical fluorinated steroids was an excellent treatment, producing near clearance of skin lesions and significant improvement in the oligoarthropathy.