Burke Christopher R, Crown Angelena, Chan Titus, McMullan D Michael
Division of Cardiac Surgery, University of Washington, Seattle, WA, United States.
Section of General Surgery, Virginia Mason Medical Center, Seattle, WA, United States.
Injury. 2017 Jan;48(1):121-126. doi: 10.1016/j.injury.2016.11.008. Epub 2016 Nov 11.
The role of extracorporeal life support (ECLS) in the critically ill trauma patient is poorly defined, possibly leading to the underutilization of this lifesaving therapy in this population. This study examined survival rates and risk factors for death in trauma patients who received ECLS.
Data from the National Trauma Data Bank was retrospectively reviewed to identify trauma patients who received ECLS from January 2012 to December 2014. Clinical outcomes and risk factors for death were examined in these patients.
Eighty patients were identified and included in the final analysis. Overall survival to hospital discharge was 64%. Survivors and non-survivors were similar in regard to age, gender, weight, and injury mechanism. Non-survivors had greater median injury severity scores (ISS) (29 non-survivors vs. 24 survivors, p=0.018) and had a shorter median total hospital length of stay (8days non-survivors vs. 32days survivors, p<0.001). Analysis of specific anatomic locations of traumatic injury, including serious head/neck, thoracic, and abdominal injuries, revealed no impact on patient survival. Multivariable logistic regression analysis identified increasing age and ISS as significant risk factors for mortality; whereas treatment at facilities that performed multiple ECLS runs over the study period was associated with improved survival.
Extracorporeal life support appears to be an effective treatment option in trauma patients with severe cardiopulmonary failure. Survival in trauma patients receiving ECLS is similar to that observed in the general ECLS population and this may represent an underutilized therapy in this population.
体外生命支持(ECLS)在重症创伤患者中的作用尚不明确,这可能导致该救命疗法在这一人群中的使用不足。本研究调查了接受ECLS的创伤患者的生存率和死亡风险因素。
对国家创伤数据库的数据进行回顾性分析,以确定2012年1月至2014年12月期间接受ECLS的创伤患者。对这些患者的临床结局和死亡风险因素进行了检查。
共识别出80例患者并纳入最终分析。总体出院生存率为64%。幸存者和非幸存者在年龄、性别、体重和损伤机制方面相似。非幸存者的中位损伤严重程度评分(ISS)更高(29分对24分,p=0.018),且中位总住院时间更短(8天对32天,p<0.001)。对创伤损伤的特定解剖部位进行分析,包括严重的头/颈部、胸部和腹部损伤,结果显示对患者生存无影响。多变量逻辑回归分析确定年龄增长和ISS是死亡的重要风险因素;而在研究期间进行多次ECLS治疗的机构接受治疗与生存率提高相关。
体外生命支持似乎是重度心肺功能衰竭创伤患者的一种有效治疗选择。接受ECLS的创伤患者的生存率与一般ECLS人群相似,这可能表明该疗法在这一人群中未得到充分利用。