自私的大脑和自私的免疫系统相互作用：情绪障碍代谢共病的理论框架。
Selfish brain and selfish immune system interplay: A theoretical framework for metabolic comorbidities of mood disorders.
机构信息
Institute of Biosciences University of São Paulo (USP). R. do Matão, 14, 321 - Butantã, São Paulo, SP, 05508-090, Brazil,; Research Group of Behavioral and Molecular Neuroscience of Bipolar Disorder, Department of Psychiatry, Federal University of São Paulo (Unifesp). R. Pedro de Toledo, 669-3rd Floor, Vila Clementino, São Paulo, SP, CEP 04039-032, Brazil.
Research Group of Behavioral and Molecular Neuroscience of Bipolar Disorder, Department of Psychiatry, Federal University of São Paulo (Unifesp). R. Pedro de Toledo, 669-3rd Floor, Vila Clementino, São Paulo, SP, CEP 04039-032, Brazil; Mood Disorders Psychopharmachology Unit (MDPU), University of Toronto. 399 Bathurst Street, MP 9-325, Toronto, Ontario, M5T 2S8, Canada.
出版信息
Neurosci Biobehav Rev. 2017 Jan;72:43-49. doi: 10.1016/j.neubiorev.2016.11.010. Epub 2016 Nov 18.
According to the "selfish brain" theory, the brain regulates its own energy supply influencing the peripheral metabolism and food intake according to its needs. The immune system has been likewise "selfish" due to independent energy consumption; and it may compete with the brain (another high energy-consumer) for glucose. In mood disorders, stress in mood episodes or physiological stress activate homeostasis mechanisms from the brain and the immune system to solve the imbalance. The interaction between the selfish brain and the selfish immune system may explain various conditions of medical impairment in mood disorders, such as Metabolic Syndrome (MetS), obesity, type 2 diabetes mellitus (T2DM) and immune dysregulation. The objective of this study is to comprehensively review the literature regarding the competition between the brain and the immune system for energy substrate. Targeting the energetic regulation of the brain and the immune system and their cross-talk open alternative treatments and a different approach in the study of general medical comorbidities in mood disorders, although more investigation is needed.
根据“自私大脑”理论，大脑会根据自身需求调节自身能量供应，从而影响外周代谢和食物摄入。免疫系统同样因为独立的能量消耗而“自私”；它可能会与大脑（另一个高能耗器官）争夺葡萄糖。在情绪障碍中，情绪发作时的压力或生理性压力会激活大脑和免疫系统的体内平衡机制来解决失衡问题。自私大脑和自私免疫系统之间的相互作用可以解释情绪障碍中各种医学损害的情况，如代谢综合征（MetS）、肥胖、2 型糖尿病（T2DM）和免疫失调。本研究的目的是全面回顾关于大脑和免疫系统争夺能量底物的文献。针对大脑和免疫系统的能量调节及其相互作用，可以为情绪障碍的一般医学共病提供新的治疗方法和研究思路，尽管还需要进一步的研究。
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