Obukhov S K, Kalashnikova V V, Khalanskiĭ A S
Zh Vopr Neirokhir Im N N Burdenko. 1989 Mar-Apr(2):30-2.
Polyclonal monospecific antibodies to the glial fibrillar antigen of the brain (GFA) and, as controls, antibodies not possessing specific tendency were injected intravenously separately into two groups of rats with glioblastomas transplanted into the brain. The immunoenzymatic method was used to study the content of the injected antibodies in tissue extracts collected from the zone of the glioblastoma, brain matter and other organs 2, 20, and 48 hours after the injection. It was established that polyclonal monospecific antibodies to GFA accumulate selectively in the zone of the glioblastoma. The use of antibodies to GFA for selective transport of medicinal agents to malignant glial tumors must be evaluated in further studies.
将针对脑胶质纤维酸性蛋白（GFA）的多克隆单特异性抗体以及作为对照的不具有特异性倾向的抗体分别静脉注射到两组移植了成胶质细胞瘤的大鼠体内。采用免疫酶法研究注射后2小时、20小时和48小时从成胶质细胞瘤区域、脑实质和其他器官收集的组织提取物中注射抗体的含量。结果表明，针对GFA的多克隆单特异性抗体选择性地聚集在成胶质细胞瘤区域。在进一步研究中必须评估使用针对GFA的抗体将药物选择性转运至恶性胶质细胞瘤的情况。
