Kobayashi Norihiro, Hirano Keisuke, Yamawaki Masahiro, Araki Motoharu, Takimura Hideyuki, Sakamoto Yasunari, Mori Shinsuke, Ito Yoshiaki
Department of Cardiology, Saiseikai Yokohama-city Eastern Hospital, Kanagawa, Japan.
Department of Cardiology, Saiseikai Yokohama-city Eastern Hospital, Kanagawa, Japan.
J Vasc Surg. 2017 Mar;65(3):744-753. doi: 10.1016/j.jvs.2016.08.106. Epub 2016 Nov 19.
The achievement of single vessel inflow to the wound is an acceptable end point of peripheral vascular intervention for patients with critical limb ischemia (CLI) with tissue loss. However, CLI patients often have multitibial artery lesions. We evaluated the clinical effects of single or double tibial artery revascularization for CLI patients.
This study was conducted retrospectively in a single center. Between April 2007 and January 2015, we treated 123 CLI patients (137 limbs) who had lesions in both the anterior tibial artery and the posterior tibial artery. Of these, single tibial artery (anterior or posterior tibial artery) revascularization was performed in 84 limbs (group S) and double tibial artery (both anterior and posterior tibial arteries) revascularization was performed in 53 limbs (group D).
The wound healing rate was significantly higher (87% vs 79%; P = .003), the time to wound healing was shorter (median, 83 vs 142 days; P = .01), and the repeat peripheral vascular intervention rate was lower (15% vs 35%; P = .03) in group D than in group S. The wound healing rate was nearly similar between the 2 groups in patients with a low clinical stage as assessed by Society for Vascular Surgery Wound, Ischemia, and foot Infection (90% in group D vs 93% in group S; P = .20); however, the wound healing rate was significantly higher in group D in patients with a high clinical stage (85% vs 72%; P = .007).
The achievement of double vessel inflows to the wound by double tibial artery revascularization positively affects wound healing, particularly in severe CLI patients.
实现伤口单一血管流入是肢体严重缺血(CLI)伴组织缺损患者外周血管介入治疗可接受的终点。然而,CLI患者常存在多支胫动脉病变。我们评估了单支或双支胫动脉血运重建对CLI患者的临床效果。
本研究为单中心回顾性研究。2007年4月至2015年1月期间,我们治疗了123例CLI患者(137条肢体),这些患者的胫前动脉和胫后动脉均有病变。其中,84条肢体进行了单支胫动脉(胫前动脉或胫后动脉)血运重建(S组),53条肢体进行了双支胫动脉(胫前动脉和胫后动脉)血运重建(D组)。
D组的伤口愈合率显著高于S组(87%对79%;P = 0.003),伤口愈合时间更短(中位数,83天对142天;P = 0.01),再次外周血管介入治疗率更低(15%对35%;P = 0.03)。根据血管外科学会伤口、缺血和足部感染评估,临床分期较低的患者中,两组的伤口愈合率相近(D组为90%,S组为93%;P = 0.20);然而,临床分期较高的患者中,D组的伤口愈合率显著更高(85%对72%;P = 0.007)。
双支胫动脉血运重建实现伤口双血管流入对伤口愈合有积极影响,尤其是在重度CLI患者中。