AlQassmi Amal, Burneo Jorge G, McLachlan Richard S, Mirsattari Seyed M
Epilepsy Program, Department of Clinical Neurological Sciences, Western University, London, Canada.
Epilepsy Program, Department of Clinical Neurological Sciences, Western University, London, Canada.
Epilepsy Behav. 2016 Dec;65:60-64. doi: 10.1016/j.yebeh.2016.09.017. Epub 2016 Nov 23.
We present a single-center retrospective study of benign mesial temporal lobe epilepsy (bMTLE) between 1995 and 2014.
Hospital records and clinic charts were reviewed. The clinical, Eelectroencephalographic (EEG), imaging features, and response to treatment with antiepileptic drugs (AEDs) were documented. Patients were included in this study if they were seizure-free for a minimum of 24months with or without an AED.
Twenty-seven patients were identified. There were 19 (70%) females, mean age at first seizure was 32.2 (range: 15-80years). In all patients, seizures were mild, and seizure freedom was readily achieved with the initiation of AED therapy. Sixteen patients (59%) had mesial temporal sclerosis (MTS). In three patients, we attempted to discontinue AED therapy after a prolonged period of remission (5-8years), but all had seizure recurrence within 2 to 4weeks.
Not all temporal lobe epilepsy is refractory to medication, despite the presence of MTS. Until clinical trials indicate otherwise, surgery is not indicated but life-long medical treatment is advocated.
我们开展了一项1995年至2014年间对良性内侧颞叶癫痫（bMTLE）的单中心回顾性研究。
查阅医院记录和临床图表。记录临床、脑电图（EEG）、影像学特征以及抗癫痫药物（AEDs）治疗反应。无论是否使用AEDs，癫痫发作至少停止24个月的患者纳入本研究。
共确定27例患者。其中女性19例（70%），首次发作的平均年龄为32.2岁（范围：15 - 80岁）。所有患者发作均较轻，开始AED治疗后很容易实现无发作。16例患者（59%）有内侧颞叶硬化（MTS）。3例患者在长时间缓解（5 - 8年）后尝试停用AED治疗，但均在2至4周内癫痫复发。
尽管存在MTS，但并非所有颞叶癫痫都对药物难治。在临床试验另有指示之前，不建议手术，但提倡终身药物治疗。
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